Alshaikh Eman M, Omar Ulfat M, Alsufiani Hadeil M, Mansouri Rasha A, Tarbiah Nesrin I, Alshaikh Abdelrhman A, Rahimulddin Sawsan A, Al Doghaither Huda A
Department of Biochemistry, Faculty of Sciences, King Abdulaziz University, Jeddah, Saudi Arabia.
Experimental Biochemistry Unit, King Fahad Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia.
Int J Health Sci (Qassim). 2019 Mar-Apr;13(2):44-47.
The aim of this study was to investigate the potential influence of hyperthyroidism on serum chemerin, visfatin, and omentin concentrations. The relationship between these adipokines and thyroid profile values was also investigated.
A total of 140 female Saudi participants aged 20-45 years were recruited and divided into two groups, the euthyroid control group ( = 70) and the hyperthyroidism group ( = 70). Chemerin, visfatin, omentin, and thyroid profile including thyroid-stimulating hormone (TSH), free triiodothyronine (FT3), free thyroxine (FT4), total triiodothyronine (TT3), total thyroxine (TT4), and thyroglobulin were measured for all participants.
Serum chemerin levels were significantly higher in patients with hyperthyroidism compared to the controls. In contrast, serum visfatin and omentin concentrations were significantly lower in hyperthyroid patients than controls. Moreover, serum chemerin concentrations were positively correlated with TT3, TT4, and FT3 and negatively correlated with TSH and FT4. A negative correlation was also found between FT4 and TT4 and serum visfatin concentrations. Inversely, TSH correlated positively with serum visfatin levels. No significant correlation was observed between serum omentin concentrations and any of the thyroid profile variables except FT3.
Hyperthyroidism influences serum chemerin, visfatin, and omentin concentrations, and these adipokines are correlated with thyroid hormones.
本研究旨在探讨甲状腺功能亢进对血清chemerin、内脂素和网膜素浓度的潜在影响。还研究了这些脂肪因子与甲状腺指标值之间的关系。
共招募了140名年龄在20 - 45岁的沙特女性参与者，分为两组，即甲状腺功能正常对照组（n = 70）和甲状腺功能亢进组（n = 70）。对所有参与者测量chemerin、内脂素、网膜素以及甲状腺指标，包括促甲状腺激素（TSH）、游离三碘甲状腺原氨酸（FT3）、游离甲状腺素（FT4）、总三碘甲状腺原氨酸（TT3）、总甲状腺素（TT4）和甲状腺球蛋白。
与对照组相比，甲状腺功能亢进患者的血清chemerin水平显著更高。相反，甲状腺功能亢进患者的血清内脂素和网膜素浓度显著低于对照组。此外，血清chemerin浓度与TT3、TT4和FT3呈正相关，与TSH和FT4呈负相关。FT4和TT4与血清内脂素浓度之间也发现呈负相关。相反，TSH与血清内脂素水平呈正相关。除FT3外，未观察到血清网膜素浓度与任何甲状腺指标变量之间存在显著相关性。
甲状腺功能亢进影响血清chemerin、内脂素和网膜素浓度，并且这些脂肪因子与甲状腺激素相关。
