Lai Lanhai, Luo Dong, Liu Ting, Zheng Wenjie, Chen Tianfeng, Li Dan
Department of Chemistry Jinan University Guangzhou 510632 GuangDong Province China) .
ChemistryOpen. 2019 Apr 2;8(4):434-437. doi: 10.1002/open.201900036. eCollection 2019 Apr.
Self-assembled functional supramolecular metallopolymers have demonstrated application potential in cancer therapy. Herein, a copper polypyridyl complex was found able to self-assemble into a supramolecular metallopolymer driven by the intermolecular interactions, which could enhance the uptake in cancer cells through endocytosis, and thus effectively inhibiting tumor growth in vivo without damaging to the major organs. This study provides a facile way to achieve enhanced anticancer efficacy by using self-assembled metallopolymers.
自组装功能性超分子金属聚合物已在癌症治疗中展现出应用潜力。在此，发现一种铜多吡啶配合物能够通过分子间相互作用自组装成超分子金属聚合物，该聚合物可通过内吞作用增强在癌细胞中的摄取，从而在体内有效抑制肿瘤生长而不损害主要器官。本研究提供了一种利用自组装金属聚合物实现增强抗癌疗效的简便方法。
