白细胞介素2增强对水痘带状疱疹病毒感染靶标的自然杀伤作用。
Interleukin 2 enhances natural killing of varicella-zoster virus-infected targets.
作者信息
Ito M, Bandyopadhyay S, Matsumoto-Kobayashi M, Clark S C, Miller D, Starr S E
出版信息
Clin Exp Immunol. 1986 Jul;65(1):182-9.
Abstract
Preincubation of peripheral blood non-adherent mononuclear cells with purified or recombinant interleukin 2 (IL-2) significantly enhanced natural killer (NK) activity against uninfected and varicella-zoster virus (VZV)-infected targets, while antibody-dependent cellular cytotoxicity (ADCC) against VZV-infected targets was not increased. Preincubation of effector cells with IL-2 had no effect on conjugate formation, but lysis of both targets was increased in single cell assays. IL-2-enhanced NK against VZV-infected targets was independent of gamma-interferon (gamma-IFN) production.
摘要
用纯化的或重组白细胞介素2（IL-2）对人外周血非贴壁单核细胞进行预孵育，可显著增强其对未感染和水痘-带状疱疹病毒（VZV）感染靶细胞的自然杀伤（NK）活性，而对VZV感染靶细胞的抗体依赖性细胞毒性（ADCC）并未增加。用IL-2对效应细胞进行预孵育对细胞结合形成没有影响，但在单细胞试验中，两种靶细胞的裂解均增加。IL-2增强的针对VZV感染靶细胞的NK活性与γ干扰素（γ-IFN）的产生无关。
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本文引用的文献
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Infect Immun. 1983 Sep;41(3):992-7. doi: 10.1128/iai.41.3.992-997.1983.
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