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白细胞介素2增强对水痘带状疱疹病毒感染靶标的自然杀伤作用。

Interleukin 2 enhances natural killing of varicella-zoster virus-infected targets.

作者信息

Ito M, Bandyopadhyay S, Matsumoto-Kobayashi M, Clark S C, Miller D, Starr S E

出版信息

Clin Exp Immunol. 1986 Jul;65(1):182-9.

PMID:3098472
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1542273/
Abstract

Preincubation of peripheral blood non-adherent mononuclear cells with purified or recombinant interleukin 2 (IL-2) significantly enhanced natural killer (NK) activity against uninfected and varicella-zoster virus (VZV)-infected targets, while antibody-dependent cellular cytotoxicity (ADCC) against VZV-infected targets was not increased. Preincubation of effector cells with IL-2 had no effect on conjugate formation, but lysis of both targets was increased in single cell assays. IL-2-enhanced NK against VZV-infected targets was independent of gamma-interferon (gamma-IFN) production.

摘要

用纯化的或重组白细胞介素2（IL-2）对人外周血非贴壁单核细胞进行预孵育，可显著增强其对未感染和水痘-带状疱疹病毒（VZV）感染靶细胞的自然杀伤（NK）活性，而对VZV感染靶细胞的抗体依赖性细胞毒性（ADCC）并未增加。用IL-2对效应细胞进行预孵育对细胞结合形成没有影响，但在单细胞试验中，两种靶细胞的裂解均增加。IL-2增强的针对VZV感染靶细胞的NK活性与γ干扰素（γ-IFN）的产生无关。

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Interleukin 2 enhances natural killing of varicella-zoster virus-infected targets.白细胞介素2增强对水痘带状疱疹病毒感染靶标的自然杀伤作用。
Clin Exp Immunol. 1986 Jul;65(1):182-9.
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本文引用的文献

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Frequency determination of K cells by a single cell cytotoxic assay.通过单细胞细胞毒性测定法确定K细胞的频率。
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Human natural killer cells analyzed by B73.1, a monoclonal antibody blocking Fc receptor functions. I. Characterization of the lymphocyte subset reactive with B73.1.用阻断Fc受体功能的单克隆抗体B73.1分析人自然杀伤细胞。I. 与B73.1反应的淋巴细胞亚群的特征。
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Interleukin 2 enhances natural killing of normal lymphocytes.白细胞介素2增强正常淋巴细胞的自然杀伤作用。
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Interleukin 2 dependence of human natural killer (NK) cell activity.人自然杀伤（NK）细胞活性对白细胞介素2的依赖性。
J Immunol. 1983 Apr;130(4):1970-3.
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Influence of lectin-free interleukin-2 on natural and antibody-dependent cellular cytotoxicity.无凝集素白细胞介素-2对自然细胞毒性和抗体依赖性细胞毒性的影响。
J Clin Lab Immunol. 1984 Oct;15(2):77-84.
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Response of resting human peripheral blood natural killer cells to interleukin 2.静息人外周血自然杀伤细胞对白介素2的反应
J Exp Med. 1984 Oct 1;160(4):1147-69. doi: 10.1084/jem.160.4.1147.
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Interleukin 2 enhances natural killer cell activity through induction of gamma interferon.白细胞介素2通过诱导γ干扰素增强自然杀伤细胞活性。
Infect Immun. 1983 Sep;41(3):992-7. doi: 10.1128/iai.41.3.992-997.1983.
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Interleukin 2 induces gamma-interferon production: participation of macrophages and NK-like cells.白细胞介素2诱导γ-干扰素生成：巨噬细胞和自然杀伤样细胞的参与
J Immunol. 1983 Jul;131(1):288-92.
9
Interleukin-2 enhances the depressed natural killer and cytomegalovirus-specific cytotoxic activities of lymphocytes from patients with the acquired immune deficiency syndrome.白细胞介素-2可增强获得性免疫缺陷综合征患者淋巴细胞中降低的自然杀伤细胞活性和巨细胞病毒特异性细胞毒性活性。
J Clin Invest. 1983 Jul;72(1):398-403. doi: 10.1172/jci110981.
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Antibody-dependent cell-mediated cytotoxicity against varicella-zoster virus-infected targets.针对水痘-带状疱疹病毒感染靶标的抗体依赖性细胞介导的细胞毒性作用
Infect Immun. 1982 Nov;38(2):554-7. doi: 10.1128/iai.38.2.554-557.1982.