评价 AdvanSure AlloScreen Max 面板检测 92 种不同变应原的过敏原特异性 IgE 水平。

Evaluation of AdvanSure AlloScreen Max Panel With 92 Different Allergens for Detecting Allergen-Specific IgE.

机构信息

Department of Laboratory Medicine, College of Medicine, The Catholic University of Korea, Seoul.

出版信息

Am J Clin Pathol. 2019 May 3;151(6):628-637. doi: 10.1093/ajcp/aqz023.

DOI:10.1093/ajcp/aqz023

PMID:30984971

Abstract

OBJECTIVES

The objective of this study was to examine the performance of AdvanSure AlloScreen Max with 92 different allergens compared to Polycheck Allergy and ImmunoCAP. The relationship of serum IgE concentration with the number and the highest class/level of positive allergen-specific IgEs was also examined.

METHODS

A total of 406 serum samples were included in this study. Discrepant cases between AdvanSure AlloScreen Max and Polycheck Allergy underwent ImmunoCAP testing for allergen-specific IgE.

RESULTS

Total agreement of the two multiple allergen simultaneous tests (MAST) was 92.5%. Compared to ImmunoCAP, total agreement rate was higher with AdvanSure AlloScreen Max (60.8%) than that with Polycheck Allergy (39.2%). Serum IgE concentration showed a significant and positive correlation with the number and the highest class/level of positive allergen-specific IgEs.

CONCLUSIONS

A MAST assay panel containing as many allergens as possible would be more helpful in the allergen screening for patients with high serum IgE concentration.

摘要

目的

本研究旨在比较 AdvanSure AlloScreen Max 与 Polycheck Allergy 和 ImmunoCAP 在检测 92 种不同过敏原时的性能。还研究了血清 IgE 浓度与阳性过敏原特异性 IgE 的数量和最高类别/级别之间的关系。

方法

本研究共纳入 406 份血清样本。AdvanSure AlloScreen Max 与 Polycheck Allergy 之间存在差异的病例进行了过敏原特异性 IgE 的 ImmunoCAP 检测。

结果

两种多重过敏原同时检测（MAST）的总符合率为 92.5%。与 ImmunoCAP 相比，AdvanSure AlloScreen Max 的总符合率（60.8%）高于 Polycheck Allergy（39.2%）。血清 IgE 浓度与阳性过敏原特异性 IgE 的数量和最高类别/级别呈显著正相关。