UMR CNRS 8060, Institute of Chemistry for Life and Health Sciences, Paris Sciences et Lettres (PSL) University, Chimie ParisTech, CSB2D Team, 75005 Paris, France.
J Org Chem. 2021 Sep 3;86(17):12054-12063. doi: 10.1021/acs.joc.1c01415. Epub 2021 Aug 10.
Enantioenriched -3-fluoro-chroman-4-ol derivatives were conveniently prepared by the ruthenium-catalyzed asymmetric transfer hydrogenation of a new family of 3-fluoro-chromanones through a dynamic kinetic resolution process. The reaction proceeded under mild conditions using a low catalyst loading and HCOH/EtN (1:1) as the hydrogen source, affording the reduced fluorinated alcohols in good yields (80-96%), high diastereomeric ratios (up to 99:1 dr), and excellent enantioselectivities (up to >99% ee).
通过动态动力学拆分过程，方便地制备了手性富集的 -3-氟色满-4-醇衍生物，通过钌催化的新型 3-氟色满酮的不对称转移氢化反应。该反应在温和的条件下进行，催化剂用量低，HCOH/EtN（1:1）为氢源，以良好的收率（80-96%）、高非对映选择性（高达 99:1 dr）和优异的对映选择性（高达>99%ee）得到还原的氟化醇。
