Lee Gunyoung, Lim Ho Soo, Yun Sang Soon, Shin Jae-Wook, Kim MeeKyung
a Food Additives and Packaging Division , National Institute of Food and Drug Safety Evaluation , Cheongju , Republic of Korea.
b Research and Planning Division , Korea Advanced Food Research Institute , Uiwang , Republic of Korea.
Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2019 Jun;36(6):876-883. doi: 10.1080/19440049.2019.1595172. Epub 2019 Apr 15.
Food additives such as antioxidants and color fixatives are substances used in food intentionally for technical effect, such as decolorizing or intensifying the color of food. Based on the necessity of re-evaluating food additives for safety and to improve consumer perception, we conducted safety assessments for food additives according to the Risk Assessment Guidelines of the Korean Ministry of Food and Drug Safety. These safety assessments evaluated new risk information based on toxicology data and estimates of dietary intake exposures to food additives in comparison with the acceptable daily intake (ADI). Estimated daily intakes (EDI) of food additives were calculated using food consumption data for the Korean population derived from the Korea National Health and Nutrition Examination Survey and monitoring data based on the analysis of food additives in food products. Unlike contaminants, antioxidants and color fixatives are purposely added as food additives, and they are largely consumed in processed foods. Therefore, EDI was compared with ADI to investigate the likelihood of potentially hazardous effects in humans. The risk likelihoods of food additives, evaluated by comparing the EDI with the ADI, were less than 2% in the total population. Thus, exposure levels to antioxidants and color fixatives do not exceed the ADI. Based on the safety assessments conducted in this study, we estimate exposure to food additives to be within safe limits for all population groups.
抗氧化剂和护色剂等食品添加剂是为了达到技术效果（如使食品脱色或增色）而有意添加到食品中的物质。基于重新评估食品添加剂安全性以及改善消费者认知的必要性，我们根据韩国食品药品安全部的风险评估指南对食品添加剂进行了安全性评估。这些安全性评估基于毒理学数据以及与每日允许摄入量（ADI）相比的食品添加剂膳食摄入暴露量估计值，对新的风险信息进行了评估。食品添加剂的估计每日摄入量（EDI）是利用来自韩国国民健康与营养检查调查的韩国人群食品消费数据以及基于食品产品中食品添加剂分析的监测数据计算得出的。与污染物不同，抗氧化剂和护色剂是作为食品添加剂特意添加的，并且它们大量用于加工食品中。因此，将EDI与ADI进行比较，以调查对人体产生潜在有害影响的可能性。通过将EDI与ADI进行比较评估得出，食品添加剂在总人口中的风险可能性低于2%。因此，抗氧化剂和护色剂的暴露水平未超过ADI。基于本研究进行的安全性评估，我们估计所有人群组对食品添加剂的暴露均在安全限值范围内。
