关于儿童癫痫与人类白细胞抗原（HLA）系统的关联。

On the association of the HLA system with epilepsy in children.

作者信息

Minev M, Martinova F, Belopitova L

出版信息

Epilepsia. 1987 Jan-Feb;28(1):74-6. doi: 10.1111/j.1528-1157.1987.tb03626.x.

DOI:10.1111/j.1528-1157.1987.tb03626.x

Abstract

HLA typing was done in 51 unrelated children with epilepsy of unknown origin. The frequency of the antigens of the loci A, B, C, and DR were compared with control groups as follows: (1,085 for the loci A and B, and 200 for C and DR). Statistically significant increased frequency of HLA-DR5 (X2 = 13.08, p less than 0.001) in the patients was demonstrated. Association between HLA-DR5 with different type of seizures was not found in this study.

摘要

对51名不明原因癫痫的非亲缘儿童进行了HLA分型。将A、B、C和DR位点抗原的频率与对照组进行如下比较：（A和B位点为1085例，C和DR位点为200例）。结果显示，患者中HLA - DR5的频率有统计学意义的增加（X2 = 13.08，p < 0.001）。本研究未发现HLA - DR5与不同类型癫痫发作之间的关联。