Metchnikoff Laboratory, University of Messina, Messina, Italy.
Metchnikoff Laboratory, University of Messina, Messina, Italy.
Biomed J. 2019 Feb;42(1):8-18. doi: 10.1016/j.bj.2018.12.009. Epub 2019 Mar 20.
One of the distinguishing features of the 1918 pandemic is the occurrence of massive, potentially detrimental, activation of the innate immune system in critically ill patients. Whether this reflects an intrinsic capacity of the virus to induce an exaggerated inflammatory responses or its remarkable ability to reproduce in vivo is still open to debate. Tremendous progress has recently been made in our understanding of innate immune responses to influenza infection and it is now time to translate this knowledge into therapeutic strategies, particularly in view of the possible occurrence of future outbreaks caused by virulent strains.
1918 年大流感的一个显著特征是重症患者的固有免疫系统会被大规模、可能有害地激活。这究竟是反映了病毒固有能力引发过度炎症反应，还是反映了其在体内繁殖的非凡能力，目前仍存在争议。最近，人们对流感感染引起的固有免疫反应的认识取得了巨大进展，现在是将这些知识转化为治疗策略的时候了，特别是考虑到未来可能由毒力更强的病毒株引发的暴发。
