重新认识抗流感策略：同等重视抗病毒治疗和抗炎治疗。
Re-understanding anti-influenza strategy: attach equal importance to antiviral and anti-inflammatory therapies.
作者信息
Li Zhengtu, Li Li, Zhao Shuai, Li Jing, Zhou Hongxia, Zhang Yunhui, Yang Zifeng, Yuan Bing
机构信息
State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, (Guangzhou Medical University), Guangzhou 510120, China.
Department of Respiration, The First Hospital of Yulin, Yulin 719000, China.
出版信息
J Thorac Dis. 2018 Jul;10(Suppl 19):S2248-S2259. doi: 10.21037/jtd.2018.03.169.
Abstract
The direct replication of influenza virus is not the only cause of harm to human health; influenza infection leading to a hyper-inflammatory immune response can also result in serious conditions. So, the treatment strategy for influenza needs to keep balance between antivirus and anti-inflammation. Herein, we review the treatment strategies of anti-influenza drugs and traditional Chinese medicines.
摘要
流感病毒的直接复制并非危害人类健康的唯一原因；流感感染引发的过度炎症免疫反应也可能导致严重病症。因此，流感的治疗策略需要在抗病毒和抗炎之间保持平衡。在此，我们综述抗流感药物和中药的治疗策略。
相似文献
1
Re-understanding anti-influenza strategy: attach equal importance to antiviral and anti-inflammatory therapies.重新认识抗流感策略：同等重视抗病毒治疗和抗炎治疗。
J Thorac Dis. 2018 Jul;10(Suppl 19):S2248-S2259. doi: 10.21037/jtd.2018.03.169.
2
[Mechanism of tonifying Qi traditional Chinese medicines contained in Yiqi Qingwen Jiedu mixture against influenza immune inflammatory injury].[益气清瘟解毒合剂中益气类中药抗流感免疫炎性损伤的机制]
Zhongguo Zhong Yao Za Zhi. 2014 Oct;39(20):4020-6.
3
[Evaluation of Chinese traditional patent medicines against influenza virus in vitro].[中药成方制剂抗流感病毒的体外评价]
Yao Xue Xue Bao. 2010 Mar;45(3):408-12.
4
Polygonum cuspidatum and its active components inhibit replication of the influenza virus through toll-like receptor 9-induced interferon beta expression.虎杖及其活性成分通过Toll样受体9诱导的β干扰素表达抑制流感病毒复制。
PLoS One. 2015 Feb 6;10(2):e0117602. doi: 10.1371/journal.pone.0117602. eCollection 2015.
5
14-Deoxy-11,12-dehydroandrographolide exerts anti-influenza A virus activity and inhibits replication of H5N1 virus by restraining nuclear export of viral ribonucleoprotein complexes.14-脱氧-11,12-去氢穿心莲内酯通过抑制病毒核糖核蛋白复合物的核输出发挥抗甲型流感病毒活性并抑制 H5N1 病毒的复制。
Antiviral Res. 2015 Jun;118:82-92. doi: 10.1016/j.antiviral.2015.03.008. Epub 2015 Mar 20.
6
Pterodontic Acid Isolated from Laggera pterodonta Inhibits Viral Replication and Inflammation Induced by Influenza A Virus.从Lagera pterodonta 中分离出的齿龈酸抑制甲型流感病毒引起的病毒复制和炎症。
Molecules. 2017 Oct 16;22(10):1738. doi: 10.3390/molecules22101738.
7
Anti-influenza agents from plants and traditional Chinese medicine.来自植物和中药的抗流感药物。
Phytother Res. 2006 May;20(5):335-41. doi: 10.1002/ptr.1892.
8
Evaluation of the anti-neuraminidase activity of the traditional Chinese medicines and determination of the anti-influenza A virus effects of the neuraminidase inhibitory TCMs in vitro and in vivo.评价中药的抗神经氨酸酶活性及体内外测定神经氨酸酶抑制中药抗流感 A 病毒的作用。
J Ethnopharmacol. 2011 Sep 1;137(1):534-42. doi: 10.1016/j.jep.2011.06.002. Epub 2011 Jun 12.
9
Mouse lung slices: An ex vivo model for the evaluation of antiviral and anti-inflammatory agents against influenza viruses.小鼠肺切片：一种用于评估抗流感病毒的抗病毒和抗炎药物的离体模型。
Antiviral Res. 2015 Aug;120:101-11. doi: 10.1016/j.antiviral.2015.05.008. Epub 2015 May 27.
10
The Chinese prescription lianhuaqingwen capsule exerts anti-influenza activity through the inhibition of viral propagation and impacts immune function.中药方剂连花清瘟胶囊通过抑制病毒增殖发挥抗流感活性，并影响免疫功能。
BMC Complement Altern Med. 2017 Feb 24;17(1):130. doi: 10.1186/s12906-017-1585-7.
引用本文的文献
1
Drugs Used in the Treatment of Viral Infections for the Prevention of Airway Remodeling in Asthma.用于治疗病毒感染以预防哮喘气道重塑的药物。
Mediators Inflamm. 2025 Jul 24;2025:5526526. doi: 10.1155/mi/5526526. eCollection 2025.
2
GPR15LG binds CXCR4 and synergistically modulates CXCL12-induced cell signaling and migration.GPR15LG与CXCR4结合，并协同调节CXCL12诱导的细胞信号传导和迁移。
Cell Commun Signal. 2025 May 20;23(1):234. doi: 10.1186/s12964-025-02231-x.
3
Uncovering the Mechanisms of BaBaoWuDanYaoMo Against Influenza A Virus and Virus-Induced Inflammation Based on Network Pharmacology and Pharmacological Evaluation.基于网络药理学和药理评价揭示八宝五胆药墨抗甲型流感病毒及病毒诱导炎症的机制
Infect Drug Resist. 2025 Jan 30;18:567-587. doi: 10.2147/IDR.S491101. eCollection 2025.
4
Tanreqing Injection Inhibits Activation of NLRP3 Inflammasome in Macrophages Infected with Influenza A Virus by Promoting Mitophagy.痰热清注射液通过促进线粒体自噬抑制甲型流感病毒感染巨噬细胞中NLRP3炎性小体的激活。
Chin J Integr Med. 2025 Jan;31(1):19-27. doi: 10.1007/s11655-024-3905-3. Epub 2024 Jun 24.
5
Genetic background influences pig responses to porcine reproductive and respiratory syndrome virus.遗传背景影响猪对猪繁殖与呼吸综合征病毒的反应。
Front Vet Sci. 2023 Oct 20;10:1289570. doi: 10.3389/fvets.2023.1289570. eCollection 2023.
6
Citri Reticulatae Pericarpium Limits TLR-4-Triggered Inflammatory Response in Raw264.7 Macrophages by Activating RasGRP3.陈皮通过激活 RasGRP3 限制 Raw264.7 巨噬细胞 TLR-4 触发的炎症反应。
Int J Mol Sci. 2023 Sep 7;24(18):13777. doi: 10.3390/ijms241813777.
7
A rapid and efficient platform for antiviral crRNA screening using CRISPR-Cas13a-based nucleic acid detection.基于 CRISPR-Cas13a 的核酸检测的抗病毒 crRNA 筛选的快速高效平台。
Front Immunol. 2023 May 9;14:1116230. doi: 10.3389/fimmu.2023.1116230. eCollection 2023.
8
Exploring the total flavones of Abelmoschus manihot against IAV-induced lung inflammation by network pharmacology.网络药理学探讨黄蜀葵花总黄酮抗甲型流感病毒诱导的肺炎症
BMC Complement Med Ther. 2022 Feb 5;22(1):36. doi: 10.1186/s12906-022-03509-0.
9
Comparison of COVID-19 and influenza characteristics.新冠病毒与流感特征比较。
J Zhejiang Univ Sci B. 2021 Feb 15;22(2):87-98. doi: 10.1631/jzus.B2000479.
10
A novel aqueous extract from rice fermented with Aspergillus oryzae and Saccharomyces cerevisiae possesses an anti-influenza A virus activity.米曲霉和酿酒酵母发酵的新型水性提取物具有抗甲型流感病毒活性。
PLoS One. 2021 Jan 15;16(1):e0244885. doi: 10.1371/journal.pone.0244885. eCollection 2021.
本文引用的文献
1
The Chinese prescription lianhuaqingwen capsule exerts anti-influenza activity through the inhibition of viral propagation and impacts immune function.中药方剂连花清瘟胶囊通过抑制病毒增殖发挥抗流感活性，并影响免疫功能。
BMC Complement Altern Med. 2017 Feb 24;17(1):130. doi: 10.1186/s12906-017-1585-7.
2
Radix isatidis Polysaccharides Inhibit Influenza a Virus and Influenza A Virus-Induced Inflammation via Suppression of Host TLR3 Signaling In Vitro.板蓝根多糖通过体外抑制宿主TLR3信号传导抑制甲型流感病毒及甲型流感病毒诱导的炎症反应。
Molecules. 2017 Jan 11;22(1):116. doi: 10.3390/molecules22010116.
3
Anti-Influenza Treatment: Drugs Currently Used and Under Development.抗流感治疗：目前使用及正在研发的药物
Arch Bronconeumol. 2017 Jan;53(1):19-26. doi: 10.1016/j.arbres.2016.07.004. Epub 2016 Aug 9.
4
Efficacy of delayed treatment of China-made Peramivir with repeated intravenous injections in a mouse influenza model: from clinical experience to basal experiment.国产帕拉米韦多次静脉注射延迟治疗在小鼠流感模型中的疗效：从临床经验到基础实验
BMC Infect Dis. 2016 Jul 8;16:325. doi: 10.1186/s12879-016-1589-9.
5
Emergence of triple-subtype reassortants of fatal human H5N6 avian influenza virus in Yunnan, China.中国云南出现致命性人感染H5N6禽流感病毒的三重亚型重配体。
J Infect. 2016 Jun;72(6):753-756. doi: 10.1016/j.jinf.2016.03.005. Epub 2016 Mar 17.
6
Correction: An Open Receptor-Binding Cavity of Hemagglutinin-Esterase-Fusion Glycoprotein from Newly-Identified Influenza D Virus: Basis for Its Broad Cell Tropism.更正：新鉴定的丁型流感病毒血凝素-酯酶-融合糖蛋白的开放受体结合腔：其广泛细胞嗜性的基础
PLoS Pathog. 2016 Mar 8;12(3):e1005505. doi: 10.1371/journal.ppat.1005505. eCollection 2016 Mar.
7
Efficacy of oseltamivir-peramivir combination therapy compared to oseltamivir monotherapy for Influenza A (H7N9) infection: a retrospective study.与奥司他韦单药治疗相比，奥司他韦-帕拉米韦联合治疗对甲型H7N9流感感染的疗效：一项回顾性研究。
BMC Infect Dis. 2016 Feb 10;16:76. doi: 10.1186/s12879-016-1383-8.
8
Up-Regulation of Pro-Inflammatory Cytokines and Chemokine Production in Avian Influenza H9N2 Virus-Infected Human Lung Epithelial Cell Line (A549).禽流感H9N2病毒感染的人肺上皮细胞系（A549）中促炎细胞因子和趋化因子产生的上调
Immunol Invest. 2016;45(2):116-29. doi: 10.3109/08820139.2015.1099663. Epub 2016 Feb 5.
9
Lariciresinol-4-O-β-D-glucopyranoside from the root of Isatis indigotica inhibits influenza A virus-induced pro-inflammatory response.来自菘蓝根的落叶松脂醇-4-O-β-D-吡喃葡萄糖苷抑制甲型流感病毒诱导的促炎反应。
J Ethnopharmacol. 2015 Nov 4;174:379-86. doi: 10.1016/j.jep.2015.08.037. Epub 2015 Aug 28.
10
Modulating the Innate Immune Response to Influenza A Virus: Potential Therapeutic Use of Anti-Inflammatory Drugs.调节对甲型流感病毒的固有免疫反应：抗炎药物的潜在治疗用途。
Front Immunol. 2015 Jul 20;6:361. doi: 10.3389/fimmu.2015.00361. eCollection 2015.
Zotero 插件