Inserm, U1235, 1 rue Gaston Veil, 44035, Nantes, France.
University Nantes, 44093, Nantes, France.
J Neurol. 2020 Aug;267(8):2207-2213. doi: 10.1007/s00415-019-09321-0. Epub 2019 Apr 12.
While the pathogenesis of Parkinson's disease is not fully understood, there is increasing evidence that inflammatory responses in the brain are implicated in both disease initiation and progression. The inflammatory process in Parkinson's disease is, however, not limited to the brain but also involves the gastrointestinal tract. High amounts of cytokines and inflammatory markers are found in the colon of Parkinson's disease patients and there is now strong epidemiological and genetical evidence linking Parkinson's disease to inflammatory bowel diseases. Recent findings obtained in both experimental inflammatory bowel diseases and Parkinson's disease further support a bidirectional link between gastrointestinal inflammation and brain neurodegeneration. Altogether, these observations suggest a role for gastrointestinal inflammation in the initiation and progression of Parkinson's disease.
虽然帕金森病的发病机制尚未完全阐明，但越来越多的证据表明，大脑中的炎症反应与疾病的发生和进展都有关联。然而，帕金森病的炎症过程不仅局限于大脑，还涉及胃肠道。帕金森病患者的结肠中发现大量细胞因子和炎症标志物，现在有强有力的流行病学和遗传学证据将帕金森病与炎症性肠病联系起来。在实验性炎症性肠病和帕金森病中获得的最新发现进一步支持了胃肠道炎症与大脑神经退行性变之间的双向联系。总之，这些观察结果表明胃肠道炎症在帕金森病的发生和进展中起作用。
