1 Department of Pediatrics, National Institute of Laser Enhanced Sciences, Cairo University, Cairo, Egypt.
2 Faculty of Medicine, Cairo University, Cairo, Egypt.
Breastfeed Med. 2019 Jul/Aug;14(6):404-407. doi: 10.1089/bfm.2018.0214. Epub 2019 Apr 26.
Breastfeeding provides optimal nutrition and health protection for the infant; it contains many anti-inflammatory factors, including transforming growth factor beta-1 (TGF-β1). Our study aimed to measure the level of TGF-β1 in human milk and to find its correlation with some infant anthropometric characteristics. A milk sample was collected from 84 mothers and the level of TGF-β1 was measured using enzyme-linked immunosorbent assay. TGF-β1 was significantly higher in vegetarian mothers compared with nonvegetarian mothers ( = 0.044). Additionally, the mean value of breast milk TGF-β1 was significantly higher in mothers using contraceptive pills compared with those who do not ( = 0.021). Also, the mean value of TGF-β1 was significantly higher in infants 3-6 months than those <3 months ( = 0.010); also there was a significant difference regarding infants' weight and length with average weight and length ( = 0.042) and ( = 0.009), respectively. TGF-β1 in human milk may play a role in infants' growth and development; mothers' diet is known to influence TGF-β1 level and its relation to infants' age and weight. Contraceptive method could have an influence on TGF-β1 levels during breastfeeding.
母乳喂养为婴儿提供最佳的营养和健康保护；它含有许多抗炎因子，包括转化生长因子β-1（TGF-β1）。我们的研究旨在测量人乳中 TGF-β1 的水平，并寻找其与一些婴儿人体测量特征的相关性。从 84 位母亲中收集了一份奶样，并使用酶联免疫吸附测定法测量了 TGF-β1 的水平。素食母亲的 TGF-β1 水平明显高于非素食母亲（=0.044）。此外，使用避孕药的母亲的母乳 TGF-β1 平均值明显高于不使用避孕药的母亲（=0.021）。此外，3-6 个月大的婴儿的 TGF-β1 平均值明显高于 <3 个月大的婴儿（=0.010）；婴儿的体重和长度也存在显著差异，平均体重和长度分别为（=0.042）和（=0.009）。人乳中的 TGF-β1 可能在婴儿的生长发育中发挥作用；众所周知，母亲的饮食会影响 TGF-β1 的水平及其与婴儿年龄和体重的关系。避孕方法可能会对母乳喂养期间的 TGF-β1 水平产生影响。
