Mari Walid, Younes Sara, Naqvi Jaree, Issa Abdelfattah Abu, Oroszi Terry L, Cool David R, Travers Jeffrey B, Simman Richard
Department of Pharmacology and Toxicology, Boonshoft School of Medicine, Wright State University, Dayton, OH.
Wounds. 2019 May;31(5):117-122. Epub 2019 Mar 15.
Chronic wounds are physically debilitating and painful and are responsible for the addition of more than $25 billion annually in health care costs in the United States. Extracellular matrix (ECM) replacements have been demonstrated to aid in wound healing by providing an optimal environment to facilitate the healing process.
This study examines the healing rates of stage 4 pressure ulcers using combination of a commercially available porcine-based wound matrix dressing alongside negative pressure wound therapy (NPWT) versus using NPWT alone.
Patients were randomized to receive either the matrix plus NPWT (study) or NPWT alone (control) for stage 4 sacral pressure ulcer treatment. Wounds were photographed and measured weekly. The experimental group had their ECM dressings changed every other week and their NPWT changed twice weekly.
A total of 16 patients, 8 study and 8 control, completed this study. After the 12-week study period, the average control patient healing rate was 45.79% as compared with the 89.98% healing rate in the study group. The difference in healing rate between control and study patients was optimal by 12 weeks.
These studies suggest that ECM dressings may be a promising adjunctive treatment option for stage 4 pressure ulcers.
慢性伤口会使人身体衰弱且疼痛，在美国，每年因慢性伤口产生的医疗费用超过250亿美元。细胞外基质（ECM）替代品已被证明可通过提供促进愈合过程的最佳环境来帮助伤口愈合。
本研究比较使用市售猪源伤口基质敷料联合负压伤口治疗（NPWT）与单独使用NPWT治疗4期压疮的愈合率。
将患者随机分组，分别接受基质加NPWT（研究组）或单独NPWT（对照组）治疗骶骨4期压疮。每周对伤口进行拍照和测量。实验组每两周更换一次ECM敷料，每周更换两次NPWT。
共有16名患者完成了本研究，其中研究组和对照组各8名。经过12周的研究期，对照组患者的平均愈合率为45.79%，而研究组为89.98%。对照组和研究组患者的愈合率差异在12周时最为显著。
这些研究表明，ECM敷料可能是治疗4期压疮的一种有前景的辅助治疗选择。
