Matsuoka M, Asou N, Hattori T, Matsuo T, Nishimura H, Takatsuki K
Acta Haematol. 1987;77(3):172-6. doi: 10.1159/000205985.
We report two patients with non-Hodgkin's lymphoma whose neoplastic cells had rearranged T cell gamma chain (T gamma) genes, and had the germ line DNA of T cell receptor beta chain (T beta) and immunoglobulin genes. Surface marker analysis of the neoplastic cells revealed that leukemic cells from one patient were derived from common thymocytes, while in the other patient the clonality and cell lineage could not be identified, probably due to the low percentage of neoplastic cells in the specimen. No phenotypic changes were observed after cultivation with phorbol myristate acetate, except for induction of Tac antigens on cells of one patient. Leukemic cells with only the T gamma gene rearrangement are thought to be precursor T cells that differentiate into mature T cells following T beta gene rearrangement. This suggests that such T cells with only the T gamma gene rearrangement exist among common thymocytes.
我们报告了两名非霍奇金淋巴瘤患者，其肿瘤细胞具有重排的T细胞γ链（Tγ）基因，且具有T细胞受体β链（Tβ）和免疫球蛋白基因的种系DNA。对肿瘤细胞的表面标志物分析显示，一名患者的白血病细胞来源于普通胸腺细胞，而另一名患者的克隆性和细胞谱系无法确定，可能是由于标本中肿瘤细胞的比例较低。用佛波酯肉豆蔻酸酯培养后，除了一名患者的细胞上诱导出Tac抗原外，未观察到表型变化。仅具有Tγ基因重排的白血病细胞被认为是前体T细胞，在Tβ基因重排后分化为成熟T细胞。这表明在普通胸腺细胞中存在这种仅具有Tγ基因重排的T细胞。
