Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, Nanjing Forestry University, Nanjing 210037, PR China; College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, PR China.
College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, PR China.
Int J Biol Macromol. 2019 Jul 15;133:148-155. doi: 10.1016/j.ijbiomac.2019.04.095. Epub 2019 Apr 13.
A novel BG composite sponge comprising of bacterial cellulose (BC) and gelatin has been synthesized using glutaraldehyde as the cross-linker by a facile method. The morphology, chemical composition and structures of the novel sponges were characterized by SEM, EDS and FTIR spectroscopy. The fabricated BG sponges have regular honeycomb-like structure with uniform pore distribution and large surface area. They have very high porosity of 94%-95% and great swelling property ranging from 3000 to 3150%. Moreover, the released rate of the model drug ampicillin (AP) from the composite sponges depends on the initial addition of AP that the diffusional constant (n) determined using Korsmeyer-Peppas model lies between 0.45 and 0.89, indicating the AP release from BG composite sponges follows non-Fickian diffusion. More interestingly, antibacterial activity of BG sponges was investigated by diffusion disk method against E.coli, C. albicans and S. aureus. The results demonstrated that the obtained BG sponges exhibit excellent antibacterial activity, thus making them have great potentials in various antibacterial applications, especially in the wound dressings.
一种新型 BG 复合海绵，由细菌纤维素 (BC) 和明胶组成，使用戊二醛作为交联剂，通过简便的方法合成。通过 SEM、EDS 和 FTIR 光谱对新型海绵的形态、化学成分和结构进行了表征。所制备的 BG 海绵具有规则的蜂窝状结构，具有均匀的孔分布和大的表面积。它们具有非常高的孔隙率（94%-95%）和出色的溶胀性能，范围从 3000 到 3150%。此外，模型药物氨苄西林 (AP) 从复合海绵中的释放率取决于 AP 的初始添加量，使用 Korsmeyer-Peppas 模型确定的扩散常数 (n) 介于 0.45 和 0.89 之间，表明 AP 从 BG 复合海绵中的释放遵循非 Fickian 扩散。更有趣的是，通过扩散盘法研究了 BG 海绵对大肠杆菌、白色念珠菌和金黄色葡萄球菌的抗菌活性。结果表明，所得到的 BG 海绵具有优异的抗菌活性，因此它们在各种抗菌应用中具有很大的潜力，特别是在伤口敷料中。
