Section for Environment, Work and Health, Danish Ramazzini Centre, Department of Public Health, Aarhus University, Bartholins Allé 2, Building 1260, DK-8000 Aarhus C, Denmark; National Research Centre for the Working Environment, Lersø Parkallé 105, DK-2100 København Ø, Denmark.
Department of Occupational Medicine, Odense University Hospital, Kløvervænget 3, indgang 138, DK-5000 Odense C, Denmark.
Environ Int. 2019 Jun;127:664-670. doi: 10.1016/j.envint.2019.02.074. Epub 2019 Apr 13.
To assess whether exposure to specific classes of neuroactive non-organochlorine insecticides is associated with diabetes mellitus or related metabolic traits.
Eligibility criteria: Any type of epidemiological and human exposure studies providing an exposure contrast to neuroactive non-organochlorine insecticides and a measure of association to diabetes mellitus or related metabolic traits. We will include published peer-reviewed studies in both English and non-English language.
Articles will be located in the NCBI PubMed, Embase, Scopus, Web of Science and LILACS databases, supplemented with manual searching of reference lists and articles citing the included studies. Risk of bias assessment: Risk of bias in individual studies will be assessed using tools from the Navigation Guide systematic review methodology, while the risk of bias at the outcome level will be assessed according to the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) guidelines. Data synthesis and analysis: When studies are sufficiently similar in population, exposure, comparator and effect estimate to meaningfully allow quantitative synthesis, we will perform meta-analysis. Otherwise, results will be summarized qualitatively.
The authors are paid employees of their respective institutions. MRHH is a Ph.D. student working under grants from Aarhus University and the National Research Centre for the Working Environment.
PROSPERO CRD42017068861.
评估接触特定类别的神经活性非有机氯杀虫剂是否与糖尿病或相关代谢特征有关。
入选标准：任何类型的流行病学和人体暴露研究，提供神经活性非有机氯杀虫剂的暴露对比，并对糖尿病或相关代谢特征进行关联测量。我们将包括英语和非英语语言的已发表同行评议研究。
文章将在 NCBI PubMed、Embase、Scopus、Web of Science 和 LILACS 数据库中定位，同时补充对参考文献列表和引用所包括研究的文章的手动搜索。偏倚风险评估：将使用导航指南系统评价方法学的工具评估单个研究的偏倚风险，而根据推荐评估、制定和评价（GRADE）指南将评估结局水平的偏倚风险。数据综合和分析：当研究在人群、暴露、对照和效应估计方面足够相似，能够进行有意义的定量综合时，我们将进行荟萃分析。否则，结果将进行定性总结。
作者是各自机构的受薪雇员。MRHH 是一名博士研究生，在奥胡斯大学和国家工作环境研究中心的资助下工作。
PROSPERO CRD42017068861。
