Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan.
Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan; Department of Psychiatry, College of Medicine, National Yang-Ming University, Taipei, Taiwan; Department of Psychiatry, Taipei Veterans General Hospital, Yuan Shan Branch, Yilan, Taiwan.
Psychiatry Res. 2019 Jun;276:25-30. doi: 10.1016/j.psychres.2019.04.014. Epub 2019 Apr 10.
Increasing evidence suggests that post-traumatic stress disorder (PTSD) interferes with the immunological system and is correlated with cardiovascular disease, respiratory disease, and chronic pain conditions. However, the association between PTSD and asthma remains unknown.
A total of 5518 patients with PTSD and 22,072 age- and sex-matched healthy individuals were enrolled between 2001 and 2009 and followed until the end of 2011. Individuals who developed asthma during the follow-up period were identified.
During the follow-up period, the patients with PTSD had an increased risk of asthma (hazard ratio [HR] = 2.27), particularly those belonging to the youngest age group (HR = 4.01). The findings were consistent in subsequent sensitivity analyses after the exclusion of the first year of surveillance or allergic disorders.
This study showed a significant link between PTSD and asthma after adjusting for demographic data and related comorbidities. The risk of developing asthma in patients with PTSD was consistently higher than that in the controls during the study period. Additional studies are necessary to clarify the underlying mechanisms involved in this association between PTSD and asthma.
越来越多的证据表明，创伤后应激障碍（PTSD）会干扰免疫系统，并与心血管疾病、呼吸道疾病和慢性疼痛状况相关。然而，PTSD 与哮喘之间的关联尚不清楚。
2001 年至 2009 年间共纳入了 5518 名 PTSD 患者和 22072 名年龄和性别匹配的健康对照者，并随访至 2011 年底。在随访期间，确定发生哮喘的个体。
在随访期间，PTSD 患者患哮喘的风险增加（风险比 [HR] = 2.27），尤其是年龄最小的那组（HR = 4.01）。在排除了第一年的监测或过敏疾病后，后续敏感性分析也得到了一致的结果。
本研究在调整了人口统计学数据和相关合并症后，显示 PTSD 与哮喘之间存在显著关联。在研究期间，PTSD 患者患哮喘的风险始终高于对照组。需要进一步的研究来阐明 PTSD 和哮喘之间这种关联的潜在机制。
