Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan.
Department of Neurology, Taipei Veterans General Hospital, Taipei, Taiwan.
Allergy. 2015 Dec;70(12):1605-12. doi: 10.1111/all.12758. Epub 2015 Sep 14.
A cross-sectional retrospective study suggested a link between allergic diseases and Parkinson's disease. However, the temporal association between asthma and Parkinson's disease remains unknown.
From the Taiwan National Health Insurance Research Database, 10 455 patients who were diagnosed with asthma between 1998 and 2008 and aged ≥45 years and 41 820 age- and sex-matched controls were selected for our study and observed until the end of 2011. Those who developed Parkinson's disease during the follow-up period were identified. We also examined the asthma severity, as indicated by the frequency of admission (times per year) for asthma exacerbation, and the risk of subsequent Parkinson's disease.
Patients with asthma had an increased risk of developing Parkinson's disease (hazard ratio [HR]: 3.10, 95% confidence interval [CI]: 2.20-4.36) after we adjusted for demographic data, health system use, medical comorbidities, and medication use. Sensitivity tests yielded consistent findings after we excluded observations on the first year (HR: 2.90, 95% CI: 2.04-4.13) and first 3 years (HR: 2.46, 95% CI: 1.64-3.69). Patients with asthma who had more frequent admissions (times per year) during the follow-up period exhibited a greater risk of subsequent Parkinson's disease (>2: HR: 16.42, 95% CI: 5.88-45.91; 1-2: 12.69, 95% CI: 5.03-31.71; 0-1: HR: 2.92, 95% CI: 1.91-4.49).
Patients with asthma had an elevated risk of developing Parkinson's disease later in life, and we observed a dose-dependent relationship between greater asthma severity and a higher risk of subsequent Parkinson's disease.
一项横断面回顾性研究表明，过敏疾病与帕金森病之间存在关联。然而，哮喘与帕金森病之间的时间关联尚不清楚。
我们从台湾全民健康保险研究数据库中选择了 10455 名 1998 年至 2008 年间被诊断患有哮喘且年龄≥45 岁的患者，以及 41820 名年龄和性别匹配的对照者进行研究，并观察至 2011 年底。在此期间，我们确定了发展为帕金森病的患者。我们还检查了哮喘的严重程度，如哮喘加重的入院次数（每年），以及随后患帕金森病的风险。
在调整了人口统计学数据、医疗系统使用情况、合并症和用药情况后，患有哮喘的患者发生帕金森病的风险增加（风险比[HR]：3.10，95%置信区间[CI]：2.20-4.36）。在排除了第一年（HR：2.90，95%CI：2.04-4.13）和前 3 年（HR：2.46，95%CI：1.64-3.69）的观察结果后，敏感性测试得出了一致的结果。在随访期间，入院次数（每年）较多的哮喘患者发生后续帕金森病的风险更高（>2 次：HR：16.42，95%CI：5.88-45.91；1-2 次：HR：12.69，95%CI：5.03-31.71；0-1 次：HR：2.92，95%CI：1.91-4.49）。
患有哮喘的患者晚年发生帕金森病的风险增加，并且我们观察到哮喘严重程度与后续帕金森病风险之间存在剂量依赖性关系。
