Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan.
Division of Psychiatry, School of Medicine, National Yang-Ming University, Taipei, Taiwan.
Stress Health. 2018 Aug;34(3):440-445. doi: 10.1002/smi.2806. Epub 2018 Apr 15.
Several studies suggested a relationship between stress and related mental illnesses, such as depression and osteoporosis. However, it was unclear whether patients with post-traumatic stress disorder (PTSD) were at risk of developing osteoporosis in later life. In this study, 6,041 patients with PTSD and 24,164 age- or sex-matched controls were enrolled between 2002 and 2009 in our study and followed up to the end of 2011. Cases of osteoporosis were identified during the follow-up. Patients with PTSD had an elevated likelihood of developing osteoporosis (HR: 2.66, 95% CI [1.91, 3.71]) in later life compared with the controls. Sensitivity tests after excluding the first year observation (HR: 2.46, 95% CI [1.72, 3.53]) and the first 3-year observation (HR: 1.88, 95% CI [1.18, 3.01]) were consistent. Patients with PTSD had a higher risk of developing osteoporosis at an earlier age compared with those without PTSD. Further studies would be necessary to clarify the pathophysiology between PTSD and osteoporosis.
多项研究表明，压力与相关精神疾病（如抑郁症和骨质疏松症）之间存在关联。然而，患有创伤后应激障碍（PTSD）的患者是否在以后的生活中面临骨质疏松症的风险尚不清楚。在这项研究中，我们在 2002 年至 2009 年间招募了 6041 名 PTSD 患者和 24164 名年龄或性别匹配的对照者，并随访至 2011 年底。在随访期间确定了骨质疏松症的病例。与对照组相比，PTSD 患者在以后的生活中发生骨质疏松症的可能性更高（HR：2.66，95%CI[1.91，3.71]）。排除第一年观察（HR：2.46，95%CI[1.72，3.53]）和前 3 年观察（HR：1.88，95%CI[1.18，3.01]）后的敏感性测试结果一致。与没有 PTSD 的患者相比，患有 PTSD 的患者更早地面临骨质疏松症的风险。需要进一步的研究来阐明 PTSD 和骨质疏松症之间的病理生理学关系。
