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The immunological basis of endotoxin-induced tumor regression. Requirement for a pre-existing state of concomitant anti-tumor immunity.内毒素诱导肿瘤消退的免疫学基础。对预先存在的伴随抗肿瘤免疫状态的要求。
J Exp Med. 1978 Dec 1;148(6):1560-9. doi: 10.1084/jem.148.6.1560.
2
The immunological basis of endotoxin-induced tumor regression. Requirement for T-cell-mediated immunity.内毒素诱导肿瘤消退的免疫学基础。T细胞介导的免疫的必要性。
J Exp Med. 1978 Dec 1;148(6):1550-9. doi: 10.1084/jem.148.6.1550.
3
The antitumor function of tumor necrosis factor (TNF) II. Analysis of the role of endogenous TNF in endotoxin-induced hemorrhagic necrosis and regression of an established sarcoma.肿瘤坏死因子（TNF）的抗肿瘤功能II。内源性TNF在脂多糖诱导的出血性坏死及已形成肉瘤消退中作用的分析。
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Modulation of antitumor immunity--immunobiologic approaches.抗肿瘤免疫调节——免疫生物学方法。
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An endotoxin-induced serum factor that causes necrosis of tumors.一种由内毒素诱导产生的、可导致肿瘤坏死的血清因子。
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Major histocompatibility complex class II-transfected tumor cells present endogenous antigen and are potent inducers of tumor-specific immunity.主要组织相容性复合体II类转染的肿瘤细胞呈递内源性抗原，是肿瘤特异性免疫的有效诱导剂。
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本文引用的文献

1
An endotoxin-induced serum factor that causes necrosis of tumors.一种由内毒素诱导产生的、可导致肿瘤坏死的血清因子。
Proc Natl Acad Sci U S A. 1975 Sep;72(9):3666-70. doi: 10.1073/pnas.72.9.3666.
2
Metastasis results from preexisting variant cells within a malignant tumor.转移是由恶性肿瘤内预先存在的变异细胞引起的。
Science. 1977 Aug 26;197(4306):893-5. doi: 10.1126/science.887927.
3
Nature of "memory" in T-cell-mediated antibacterial immunity: anamnestic production of mediator T cells.T细胞介导的抗菌免疫中“记忆”的本质：调节性T细胞的回忆性产生
Infect Immun. 1975 Oct;12(4):754-60. doi: 10.1128/iai.12.4.754-760.1975.
4
T-cell-mediated concomitant immunity to syngeneic tumors. I. Activated macrophages as the expressors of nonspecific immunity to unrelated tumors and bacterial parasites.T细胞介导的对同基因肿瘤的伴随免疫。I. 活化巨噬细胞作为对无关肿瘤和细菌寄生虫非特异性免疫的表达者。
J Exp Med. 1977 Feb 1;145(2):275-92. doi: 10.1084/jem.145.2.275.
5
Induction and immunological properties of tumor necrosis factor.肿瘤坏死因子的诱导及免疫学特性
J Reticuloendothel Soc. 1978 Apr;23(4):307-19.
6
Corynebacterium parvum as the priming agent in the production of tumor necrosis factor in the mouse.短小棒状杆菌作为小鼠肿瘤坏死因子产生中的启动剂。
J Natl Cancer Inst. 1977 Nov;59(5):1519-22. doi: 10.1093/jnci/59.5.1519.
7
The immunological basis of endotoxin-induced tumor regression. Requirement for T-cell-mediated immunity.内毒素诱导肿瘤消退的免疫学基础。T细胞介导的免疫的必要性。
J Exp Med. 1978 Dec 1;148(6):1550-9. doi: 10.1084/jem.148.6.1550.
8
Partial purification of a serum factor that causes necrosis of tumors.
Proc Natl Acad Sci U S A. 1976 Feb;73(2):381-5. doi: 10.1073/pnas.73.2.381.

内毒素诱导肿瘤消退的免疫学基础。对预先存在的伴随抗肿瘤免疫状态的要求。

The immunological basis of endotoxin-induced tumor regression. Requirement for a pre-existing state of concomitant anti-tumor immunity.

作者信息

Berendt M J, North R J, Kirstein D P

出版信息

J Exp Med. 1978 Dec 1;148(6):1560-9. doi: 10.1084/jem.148.6.1560.

DOI:10.1084/jem.148.6.1560
PMID:309922
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2185097/
Abstract

It was shown that of four syngeneic, murine tumors investigated, only those that evoked the generation of a state of concomitant anti-tumor immunity were susceptible to endotoxin-induced regression. Moreover, the temporal relationship between the generation of concomitant immunity and the onset of susceptibility to endotoxin-induced regression points to the likely possibility that tumor regression depends on the preceding acquisition of the specifically-sensitized, effector T cells that express concomitant immunity. It is suggested that endotoxin-induced hemorrhagic necrosis which invariably precedes tumor regression serves to create conditions inside the tumor that are conducive to the entry and the functioning of effector T cells. It is also suggested that tumor necrosis factor causes hemorrhagic necrosis rather than tumor regression.

摘要

结果表明，在所研究的四种同基因小鼠肿瘤中，只有那些能引发伴随抗肿瘤免疫状态的肿瘤对内毒素诱导的消退敏感。此外，伴随免疫的产生与对内毒素诱导消退的易感性开始之间的时间关系表明，肿瘤消退可能取决于先前获得表达伴随免疫的特异性致敏效应T细胞。有人提出，肿瘤消退之前必然发生的内毒素诱导的出血性坏死有助于在肿瘤内部创造有利于效应T细胞进入和发挥作用的条件。也有人提出，肿瘤坏死因子导致出血性坏死而非肿瘤消退。