Hosseininasab Nodoushan Seyed Abolfazl, Nabavi Amin
Department of Microbiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Department of Biochemistry, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Adv Biomed Res. 2019 Feb 27;8:15. doi: 10.4103/abr.abr_37_18. eCollection 2019.
is one of the most common human pathogens that can cause gastrointestinal (GI) disorders, including simple gastritis, gastric ulcer, and malignant gastritis. In some cases, such as immunodeficiency and underlying diseases, it can be problematic as opportunistic infections. Diabetes mellitus (type 2) (T2DM) is one of the H. pylori underlying diseases. Since GI problems are observed in diabetic patients, it is necessary to treat infection. In this review, we aimed to evaluate the possible relationship between and T2DM according to epidemiological surveys of 70 studies retrieved from databases, including Scopus, PubMed, and Google Scholar about the relationship between and T2DM, and discuss the reported background mechanisms of this correlation. According to the results of our study, the different studies have shown that is more prevalent in Type 2 diabetic patients than healthy individuals or nondiabetic patients. The reason is development of infection-induced inflammation and production of inflammatory cytokines as well as different hormonal imbalance by this bacterium, which are associated with diabetes mellitus. On the other hand, by tracing anti- antibodies in patients with diabetes mellitus and occurrence of symptoms such as digestive problems in >75% of these patients, it can be concluded that there is a relationship between this bacterium and T2DM. Considering the evidence, it is crucially important that the probability of infection with is evaluated in patients with T2DM so that medical process of the patient is followed with higher cautious.
是最常见的人类病原体之一，可导致胃肠道疾病，包括单纯性胃炎、胃溃疡和恶性胃炎。在某些情况下，如免疫缺陷和基础疾病，它作为机会性感染可能会引发问题。2型糖尿病（T2DM）是幽门螺杆菌相关的基础疾病之一。由于在糖尿病患者中观察到胃肠道问题，因此有必要治疗感染。在本综述中，我们旨在根据从Scopus、PubMed和谷歌学术等数据库检索到的70项关于幽门螺杆菌与T2DM关系的研究的流行病学调查，评估幽门螺杆菌与T2DM之间的可能关系，并讨论报道的这种相关性的背景机制。根据我们的研究结果，不同的研究表明，幽门螺杆菌在2型糖尿病患者中比健康个体或非糖尿病患者中更普遍。原因是幽门螺杆菌感染引起的炎症发展、炎性细胞因子的产生以及该细菌导致的不同激素失衡，这些都与糖尿病有关。另一方面，通过追踪糖尿病患者体内的抗幽门螺杆菌抗体，以及这些患者中超过75%出现消化问题等症状，可以得出结论，这种细菌与T2DM之间存在关联。考虑到这些证据，在2型糖尿病患者中评估幽门螺杆菌感染的可能性至关重要，以便更谨慎地跟踪患者的医疗过程。
