Zojaji Homayon, Ataei Elnaz, Sherafat Somayeh Jahani, Ghobakhlou Mehdi, Fatemi Seyed Reza
Gastroenterology and Liver Disease Research Cancer, Shahid Beheshti University of Medical sciences, Tehran, Iran.
Gastroenterol Hepatol Bed Bench. 2013 Winter;6(1):36-40.
To evaluate the possible long-term effects of Helicobacter pylori infection on Hemoglobin A1c and fasting blood sugar levels in patients with type 2 diabetes.
Helicobacter pylori causes the gastrointestinal tract inflammation, which it plays an important role in distortion of glucose and lipids absorption that altered lipid metabolism and energy harvesting and develops type 2 diabetes, insulin resistance and has been linked to impaired blood glucose.
In this clinical trial, patients with type 2 diabetes and confirmed Helicobacter pylori infection were recruited from the endocrinology clinic of the Shahid Beheshti University Tehran, Iran. Before and after 3 months of eradication therapy fasting blood samples were taken and glycalated hemoglobin levels and fasting blood sugar levels were measured.
85 (27 male 31.8%, 58 female 68.2%) patients with the mean age of 52.±4.7 years were recruited. 52 (62%) had successful Helicobacter pylori eradication (16 male, 30.8% and 36 female, 69.2%). The mean glycalated haemoglobin levels before successful treatment was 8.7±1.1 and after treatment was 8.3±0.9 and difference was significant (p<0.001). Mean IgG level of serology was 3.3±1.1 and the correlation with glycalated haemoglobin was significant (p=0.02) (r=0.4).
Our results indicate that the Helicobacter pylori treatment can improve the mean glycalated haemoglobin in patients with type 2 diabetes. More investigations will be required to evaluate the effects of Helicobacter pylori eradication among different age groups and in relation to obesity status, diabetes and other disease, and it may be beneficial for patients at risk of diabetes to be checked for the presence of Helicobacter pylori infection.
评估幽门螺杆菌感染对2型糖尿病患者糖化血红蛋白和空腹血糖水平可能产生的长期影响。
幽门螺杆菌会引发胃肠道炎症，在葡萄糖和脂质吸收紊乱中起重要作用，这种紊乱会改变脂质代谢和能量获取，进而引发2型糖尿病、胰岛素抵抗，并与血糖受损有关。
在这项临床试验中，从伊朗德黑兰谢赫·贝赫什提大学内分泌科诊所招募了确诊为幽门螺杆菌感染的2型糖尿病患者。在根除治疗前及治疗3个月后采集空腹血样，测量糖化血红蛋白水平和空腹血糖水平。
共招募了85名患者（27名男性，占31.8%；58名女性，占68.2%），平均年龄为52±4.7岁。52名患者（62%）成功根除了幽门螺杆菌（16名男性，占30.8%；36名女性，占69.2%）。成功治疗前糖化血红蛋白的平均水平为8.7±1.1，治疗后为8.3±0.9，差异具有统计学意义（p<0.001）。血清学平均IgG水平为3.3±1.1，与糖化血红蛋白的相关性具有统计学意义（p=0.02）（r=0.4）。
我们的结果表明，幽门螺杆菌治疗可改善2型糖尿病患者的平均糖化血红蛋白水平。需要更多研究来评估在不同年龄组中根除幽门螺杆菌的效果，以及与肥胖状况、糖尿病和其他疾病的关系，对有糖尿病风险的患者进行幽门螺杆菌感染检测可能有益。
