富含大麻二酚的软膏对炎症性皮肤病和皮肤瘢痕的治疗作用。
A therapeutic effect of cbd-enriched ointment in inflammatory skin diseases and cutaneous scars.
作者信息
Palmieri B, Laurino C, Vadalà M
机构信息
Department of General Surgery and Surgical Specialties, University of Modena and Reggio Emilia Medical School, Surgical Clinic, Modena - Second Opinion Medical Network, Modena (MO), Italy.
出版信息
Clin Ter. 2019 Mar-Apr;170(2):e93-e99. doi: 10.7417/CT.2019.2116.
OBJECTIVE
To investigate the therapeutic effect of CBD-ointment administered on severe skin chronic diseases and/or on their outcome scars.
METHODS
A spontaneous, anecdotal, retrospective study of 20 patients with two most frequent skin disorders: psoriasis (n: 5 patients), atopic dermatitis (n: 5) and resulting outcome scars (n: 10). The subjects were instructed to administer topical CBD-enriched ointment to lesioned skin areas twice daily for three months treatment.
RESULTS
Based on skin evaluations (hydration, TEWL, elasticity), clinical questionnaires (SCORAD, ADI, PASI), and supported by photographic data and investigators' clinical assessment, the results showed that topical treatment with CBD-enriched ointment significantly improved the skin parameters, the symptoms and also the PASI index score. No irritant or allergic reactions were documented during the period treatment.
CONCLUSIONS
The topical administration of CBD ointment, without any THC, is a safe and effective non-invasive alternative for improve the quality of life in patients with some skin disorders, especially on inflammatory background.
目的
研究不含四氢大麻酚（THC）的大麻二酚（CBD）软膏对严重皮肤慢性疾病及其遗留疤痕的治疗效果。
方法
对20例患有两种最常见皮肤疾病的患者进行了一项自发性、轶事性、回顾性研究，其中银屑病患者5例、特应性皮炎患者5例，以及由此产生的疤痕患者10例。受试者被指示每天两次在皮损部位涂抹富含CBD的软膏，持续治疗三个月。
结果
基于皮肤评估（水合作用、经表皮水分流失、弹性）、临床问卷（特应性皮炎严重程度评分指数、特应性皮炎面积和严重程度指数、银屑病面积和严重程度指数），并辅以照片数据和研究者的临床评估，结果显示，涂抹富含CBD的软膏进行局部治疗可显著改善皮肤参数、症状以及银屑病面积和严重程度指数评分。在治疗期间未记录到刺激性或过敏反应。
结论
不含任何THC的CBD软膏局部给药，是改善某些皮肤疾病患者生活质量的一种安全有效的非侵入性替代方法，尤其是对有炎症背景的患者。
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