Larsson Jim, Leander Dennis, Lewander Xu Märta, Fellman Vineta, Bood Joakim, Krite Svanberg Emilie
Division of Combustion Physics, Department of Physics, Lund University, Lund, Sweden.
GPX Medical AB, Lund, Sweden.
J Biophotonics. 2019 Aug;12(8):e201800350. doi: 10.1002/jbio.201800350. Epub 2019 May 2.
Oxygen and water vapor content, in the lungs of a 3D-printed phantom model based on CT-images of a preterm infant, is evaluated using Tunable Diode Laser Absorption Spectroscopy (TDLAS) in Gas in Scattering Media Absorption Spectroscopy (GASMAS), that is, the TDLAS-GASMAS technique. Oxygen gas is detected through an absorption line near 764 nm and water vapor through an absorption line near 820 nm. A model with a lung containing interior structure is compared to a model with a hollow lung. Compared to the model with the hollow lung, both the mean absorption path length and the transmitted intensity are found to be lower for the model with the structured lung. A new approach, where laser light is delivered internally into the model through an optical fiber, is compared to dermal light administration, that is, illumination onto the skin, for the model with structure inside the lung. The internal light administration generally resulted in larger gas absorption, and higher signal-to-noise ratios, compared to the dermal light administration. The results from the phantom measurements show great promise for the internal illumination approach and a natural next step would be to investigate it further in clinical studies.
在基于早产儿CT图像的3D打印体模模型的肺部中，利用气体在散射介质中的吸收光谱（GASMAS）中的可调谐二极管激光吸收光谱（TDLAS）技术，即TDLAS - GASMAS技术，对氧气和水蒸气含量进行评估。通过764 nm附近的吸收线检测氧气，通过820 nm附近的吸收线检测水蒸气。将具有内部结构的肺部模型与空心肺部模型进行比较。与空心肺部模型相比，发现具有结构化肺部的模型的平均吸收路径长度和透射强度都更低。对于肺部内部有结构的模型，将一种通过光纤将激光内部传输到模型中的新方法与皮肤表面光给药（即照射到皮肤上）进行比较。与皮肤表面光给药相比，内部光给药通常会导致更大的气体吸收和更高的信噪比。体模测量结果显示了内部照明方法的巨大潜力，下一步自然是在临床研究中进一步研究它。
