Larsson Jim, Liao Peilang, Lundin Patrik, Krite Svanberg Emilie, Swartling Johannes, Lewander Xu Märta, Bood Joakim, Andersson-Engels Stefan
Division of Combustion Physics, Department of Physics, Lund University, Lund, Sweden.
Department of Physics, Lund University, Lund, Sweden.
J Biophotonics. 2018 Mar;11(3). doi: 10.1002/jbio.201700097. Epub 2017 Sep 14.
There is a need to further improve the clinical care of our most vulnerable patients-preterm infants. Novel diagnostic and treatment tools facilitate such advances. Here, we evaluate a potential percutaneous optical monitoring tool to assess the oxygen and water vapor content in the lungs of preterm babies. The aim is to prepare for further clinical studies by gaining a detailed understanding of how the measured light intensity and gas absorption signal behave for different possible geometries of light delivery and receiver. Such an experimental evaluation is conducted for the first time utilizing a specially developed 3-dimensional-printed optical phantom based on a geometry model obtained from computer tomography images of the thorax (chest) of a 1700-g premature infant. The measurements yield reliable signals for source-detector distances up to about 50 mm, with stronger gas absorption signals at long separations and positions related to the lower part of the lung, consistent with a larger relative volume of this. The limitations of this study include the omission of scattering tissue within the lungs and that similar optical properties are used for the wavelengths employed for the 2 gases, yielding no indication on the optimal wavelength pair to use.
有必要进一步改善对我们最脆弱的患者——早产儿的临床护理。新型诊断和治疗工具推动了这方面的进展。在此，我们评估一种潜在的经皮光学监测工具，以评估早产婴儿肺部的氧气和水蒸气含量。目的是通过详细了解对于不同可能的光传输和接收器几何形状，测量的光强度和气体吸收信号的表现，为进一步的临床研究做准备。首次利用基于从一名1700克早产婴儿胸部的计算机断层扫描图像获得的几何模型特制的三维打印光学模型进行了这样的实验评估。测量结果在源探测器距离达约50毫米时产生可靠信号，在较长距离以及与肺下部相关的位置有更强的气体吸收信号，这与该部位相对较大的体积一致。本研究的局限性包括未考虑肺内的散射组织，以及两种气体所采用的波长使用了相似的光学特性，未给出关于最佳波长对的指示。
