Purjeranta M, Rechardt L, Pelto-Huikko M, Kyösola K
Virchows Arch A Pathol Anat Histopathol. 1986;410(2):147-51. doi: 10.1007/BF00713519.
Neuropeptide Y (NPY)-like immunoreactive nerves were demonstrated in human cardiac muscle. The atrial specimens were obtained from open-heart surgery. The PAP method was applied for immunocytochemistry for light and electron microscopy. A dense, extensive network of NPY-like immunoreactive nerve fibres was seen between cardiac muscle cells and around blood vessels. In electron microscope PAP precipitates were localized in large dense-cored vesicles of 80-120 nm in size in separate nerve terminals or in the terminals situated in the nerve bundles. Close contacts were observed between NPY nerves and muscle cells and blood vessels. The possible functional role of NPY innervation in the human heart is discussed.
在人类心肌中发现了神经肽Y（NPY）样免疫反应性神经。心房标本取自心脏直视手术。采用PAP法进行免疫细胞化学染色，用于光学显微镜和电子显微镜观察。在心肌细胞之间和血管周围可见密集、广泛的NPY样免疫反应性神经纤维网络。在电子显微镜下，PAP沉淀物定位于大小为80 - 120 nm的大型致密核心囊泡中，这些囊泡位于单独的神经末梢或神经束中的末梢内。观察到NPY神经与肌肉细胞和血管之间有紧密接触。文中讨论了NPY神经支配在人类心脏中可能的功能作用。
