用龙胆紫联合冷冻疗法局部治疗旧世界皮肤利什曼病：一项试点单盲随机对照临床试验。
The topical treatment of old world cutaneous leishmaniasis with gentian violet along with cryotherapy: a pilot single-blind randomized controlled clinical trial.
作者信息
Sepaskhah Mozhdeh, Behdad Kasra, Bagheri Zahra
机构信息
Molecular Dermatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Department of Biostatistics, Shiraz University of Medical Sciences, Shiraz, Iran.
出版信息
Rev Soc Bras Med Trop. 2019 Apr 11;52:e20180278. doi: 10.1590/0037-8682-0278-2018.
INTRODUCTION
The promising non-clinical antileishmanial effects of gentian violet (GV) encouraged us to evaluate the additive effect of GV on cryotherapy.
METHODS
For 8 weeks, 59/161 cutaneous leishmaniasis patients/lesions underwent cryotherapy alone (group 1) or cryotherapy accompanied by 1% GV application (group 2). The primary endpoint was clinical response.
RESULTS
Ultimately, 54.7% and 45.3% of the significantly cured lesions belonged to groups 1 and 2, respectively, which was not statistically significant. The clinical response was significantly different between the two groups at the end of the fourth week.
CONCLUSIONS
Although the clinical response of the two groups was significantly different at the end of the fourth week, application of GV did not increase the efficacy of cryotherapy.
引言
龙胆紫（GV）有前景的非临床抗利什曼原虫作用促使我们评估其对冷冻疗法的增效作用。
方法
8周内，161例皮肤利什曼病患者的59个皮损单独接受冷冻疗法（第1组）或在冷冻疗法的同时应用1%的龙胆紫（第2组）。主要终点是临床反应。
结果
最终，显著治愈的皮损中，第1组和第2组分别占54.7%和45.3%，差异无统计学意义。在第4周结束时，两组的临床反应有显著差异。
结论
虽然两组在第4周结束时的临床反应有显著差异，但应用龙胆紫并未提高冷冻疗法的疗效。
Zotero 插件