Mercier Gregoire, Pastor Jenica, Moffatt Christine, Franks Peter, Quéré Isabelle
1 CHU de Montpellier, Montpellier, France.
2 CEPEL, UMR 5112 CNRS Université de Montpellier, Montpellier, France.
Lymphat Res Biol. 2019 Apr;17(2):163-167. doi: 10.1089/lrb.2018.0084.
Chronic edema is a condition posing a high burden on patients. The primary aim of the study was to assess the health-related quality of life (QoL) of adult patients living with chronic edema. As part of an international, multicenter, prospective study, we prospectively assessed the health-related QoL of adult patients living with a chronic edema using a disease-specific tool and a generic one. In total, 1094 patients were included, aged 57 years on average. The average EQ-5D and LYMQOL visual analogue scale (VAS) scores were equal to 63.6 (SD = 20.2) and 6.3 (SD = 2.0), respectively. After adjustment, the EQ-5D VAS was explained by LYMQOL VAS (β = 7.85; < 0.001), age (β = -0.08; = 0.02), obesity (β = -1.89; = 0.001), and male gender (β = 3.32; = 0.002). As for the LYMQOL VAS, it was independently associated with EQ-5D VAS (β = 0.07; < 0.001), LYMQOL function (β = -0.21; < 0.001), and LYMQOL mood (β = -0.49; < 0.001). This study confirms that patients living with a chronic edema experience a poor disease-specific and generic health-related QoL.
慢性水肿是一种给患者带来沉重负担的病症。该研究的主要目的是评估成年慢性水肿患者的健康相关生活质量（QoL）。作为一项国际多中心前瞻性研究的一部分，我们使用一种疾病特异性工具和一种通用工具对成年慢性水肿患者的健康相关QoL进行了前瞻性评估。总共纳入了1094例患者，平均年龄为57岁。EQ - 5D和LYMQOL视觉模拟量表（VAS）的平均得分分别为63.6（标准差 = 20.2）和6.3（标准差 = 2.0）。调整后，LYMQOL VAS可解释EQ - 5D VAS（β = 7.85；<0.001）、年龄（β = -0.08；= 0.02）、肥胖（β = -1.89；= 0.001）和男性性别（β = 3.32；= 0.002）。至于LYMQOL VAS，它与EQ - 5D VAS（β = 0.07；<0.001）、LYMQOL功能（β = -0.21；<0.001）和LYMQOL情绪（β = -0.49；<0.001）独立相关。这项研究证实，成年慢性水肿患者在疾病特异性和通用健康相关QoL方面表现较差。
