使用光氧化还原/路易斯酸协同催化实现亚芳基丙二酸酯与不饱和亲电试剂的还原环化反应。
Reductive annulations of arylidene malonates with unsaturated electrophiles using photoredox/Lewis acid cooperative catalysis.
作者信息
Betori Rick C, McDonald Benjamin R, Scheidt Karl A
机构信息
Department of Chemistry , Center for Molecular Innovation and Drug Discovery , Northwestern University , 2145 Sheridan Road , Evanston , Illinois 60208 , USA . Email:
出版信息
Chem Sci. 2019 Feb 6;10(11):3353-3359. doi: 10.1039/c9sc00302a. eCollection 2019 Mar 21.
Abstract
A cooperative Lewis acid/photocatalytic reduction of salicylaldehyde-derived arylidene malonates provides access to a versatile, stabilized radical anion enolate. Using these unusual umpolung operators, we have developed a novel route to access densely functionalized carbo- and heterocycles through a radical annulation addition pathway.
摘要
通过协同的路易斯酸/光催化还原水杨醛衍生的亚芳基丙二酸酯，可以得到一种通用的、稳定的自由基阴离子烯醇盐。利用这些不同寻常的极性翻转试剂，我们开发了一条通过自由基环化加成途径获得高度官能化的碳环和杂环的新路线。
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