Pharmacology and Therapeutics, Faculty of Medicine, University of Valladolid, Valladolid.
Nephrology, Hospital Virgen de la Concha - Sanidad de Castilla y León, Zamora.
Int Clin Psychopharmacol. 2019 Jul;34(4):184-188. doi: 10.1097/YIC.0000000000000263.
Antipsychotics are considered driving-impairing medicines. A population-based registry study design was conceived to assess the year-2016 antipsychotic dispensation in Castile and León, Spain. Weighting was performed to obtain the adjusted antipsychotic consumption for licensed drivers according to age and gender using the Spanish national drivers' license census data. In 2016, antipsychotics were dispensed to 3.86% of the general population and 2.71% of licensed drivers. Antipsychotic use was higher in females (4.72%) than in males (2.98%), and increased as age increased, but women drivers used less antipsychotics after 60 years old. Chronic antipsychotic use (≥30 days) accounted for 1.62%. Typical antipsychotics predominated among acute users (1.60% versus 0.09%), while atypical antipsychotics were the rule in chronic use (1.41% versus 0.36%). A concomitant use of antipsychotics with other driving-impairing medicines was also common. This study is intended for updating the epidemiological knowledge of all involved in the control of use of antipsychotics and other driving-impairing medicines (healthcare providers, patients, authorities, and drug developers) in order to improve prescribing/dispensing and a well tolerated use of all driving-impairing medicines by the population. Awareness is needed to improve safety on driving, and there is a need worldwide to improve interventions in the field of medicines and driving.
抗精神病药被认为是会影响驾驶能力的药物。为了评估 2016 年西班牙卡斯蒂利亚-莱昂地区的抗精神病药配给情况，开展了一项基于人群的登记研究设计。根据年龄和性别，使用西班牙国家驾驶执照普查数据对许可驾驶员进行加权，以获得调整后的抗精神病药消费情况。2016 年，普通人群中有 3.86%和有照驾驶员中有 2.71%使用了抗精神病药。女性（4.72%）比男性（2.98%）使用抗精神病药的比例更高，且随着年龄的增长而增加，但女性驾驶员在 60 岁以后使用的抗精神病药较少。慢性抗精神病药（≥30 天）的使用占 1.62%。在急性使用者中，典型抗精神病药占主导地位（1.60%比 0.09%），而在慢性使用者中，非典型抗精神病药则更为常见（1.41%比 0.36%）。抗精神病药与其他会影响驾驶能力的药物同时使用也很常见。本研究旨在更新与控制抗精神病药和其他会影响驾驶能力的药物（医疗保健提供者、患者、当局和药物开发者）的使用相关的所有方面的流行病学知识，以便改善所有会影响驾驶能力的药物的处方/配给情况，使人群能够耐受地使用这些药物。需要提高对驾驶安全的认识，全世界都需要改进药物和驾驶领域的干预措施。
