Herrera-Gómez Francisco, Gutierrez-Abejón Eduardo, Criado-Espegel Paloma, Álvarez F Javier
Pharmacology and Therapeutics, Faculty of Medicine, University of Valladolid, Valladolid, Spain.
Nephrology, Hospital Virgen de la Concha - Sanidad de Castilla y León, Zamora, Spain.
Front Pharmacol. 2018 Apr 26;9:408. doi: 10.3389/fphar.2018.00408. eCollection 2018.
Benzodiazepines are driving-impairing medicines (DIM). This study presents current consumption of dispensed benzodiazepines in the Spanish general population, with a focus in pattern of use and concomitant medicines consumed with. A population-based registry study was carried out to assess the year-2016 granted benzodiazepines dispensation in Castile and León. Weighting was performed to obtain the adjusted benzodiazepine consumption for licensed drivers according to age and gender using our national drivers' license census data. Benzodiazepines were used by 15.38% of the general population and 10.97% of drivers. Nearly 2% of the population and more than 1% of drivers took these medicines every day. The amount consumed (until 3 or more benzodiazepines day) and concomitant use of other DIM were also higher. Women were the most frequent consumers, and anxiolytic use was usual. Consumption increases with age, but there were differences between men and women drivers from 60 years old. The current use of benzodiazepines must serve to awareness of the healthcare personnel, patients, and authorities on their risks, above all on the road safety.
苯二氮䓬类药物是会影响驾驶能力的药物（DIM）。本研究展示了西班牙普通人群中苯二氮䓬类药物的当前配药使用情况，重点关注其使用模式以及与之同时服用的其他药物。开展了一项基于人群的登记研究，以评估2016年卡斯蒂利亚-莱昂地区苯二氮䓬类药物的配药情况。根据我国驾照普查数据，按年龄和性别进行加权计算，得出持照驾驶员调整后的苯二氮䓬类药物消费量。普通人群中15.38%的人使用苯二氮䓬类药物，驾驶员中这一比例为10.97%。近2%的普通人群和超过1%的驾驶员每天服用这些药物。（每天服用3种或更多苯二氮䓬类药物的情况下）药物消费量以及与其他影响驾驶能力药物的同时使用情况也更高。女性是最常使用这类药物的人群，且通常使用抗焦虑药物。药物消费量随年龄增长而增加，但60岁及以上男性和女性驾驶员之间存在差异。当前苯二氮䓬类药物的使用情况必须促使医护人员、患者和当局意识到其风险，尤其是对道路安全的风险。
