Jeong Su Jin
Department of Pediatrics, Bundang CHA Medical Center, CHA University School of Medicine, Seongnam, Korea.
Korean J Pediatr. 2019 Aug;62(8):287-291. doi: 10.3345/kjp.2019.00059. Epub 2019 Mar 28.
Fecal calprotectin (FC) is a calcium- and zinc-binding protein of the S100 family, mainly expressed by neutrophils and released during inflammation. FC became an increasingly useful tool both for gastroenterologists and for general practitioners for distinguishing inflammatory bowel disease (IBD) from irritable bowel syndrome. Increasing evidences support the use of this biomarker for diagnosis, follow-up and evaluation of response to therapy of several pediatric gastrointestinal diseases, ranging from IBD to nonspecific colitis and necrotizing enterocolitis. This article summarizes the current literature on the use of FC in clinical practice.
粪便钙卫蛋白（FC）是S100家族的一种钙结合和锌结合蛋白，主要由中性粒细胞表达并在炎症期间释放。FC对于胃肠病学家和全科医生而言，已成为区分炎症性肠病（IBD）和肠易激综合征越来越有用的工具。越来越多的证据支持将这种生物标志物用于多种儿科胃肠疾病的诊断、随访及治疗反应评估，范围从IBD到非特异性结肠炎和坏死性小肠结肠炎。本文总结了目前关于FC在临床实践中应用的文献。
