State Key Laboratory of Oral Diseases, Department of Oral and Maxillofacial Surgery, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology (Sichuan University), Chengdu, China.
Key Laboratory of Fermentation Engineering (Ministry of Education), Hubei Key Laboratory of Industrial Microbiology, Hubei Provincial Cooperative Innovation Center of Industrial Fermentation, Hubei University of Technology, Wuhan, China.
Front Immunol. 2019 Apr 2;10:653. doi: 10.3389/fimmu.2019.00653. eCollection 2019.
Patients with human papilloma virus (HPV)-associated head and neck squamous cell carcinoma (HNSCC) have remarkably better prognosis, which differs from HPV-negative oropharyngeal squamous cell carcinoma (OPSCC) with respect to clinical, genomic, molecular, and immunological aspects, especially having the characteristics of high levels of immune cell infiltration and high degrees of immunosuppression. This review will summarize immune evasion mechanisms in HPV-positive HNSCC, analyze the host various immune responses to HPV and abundant numbers of infiltrating immune cell, and discuss the differences between HPV-positive HNSCC with cervical cancer. A deeper understanding of the immune landscape will help new concepts to emerge in immune-checkpoint oncology, which might be a valuable add-on to established concepts.
人乳头瘤病毒（HPV）相关的头颈部鳞状细胞癌（HNSCC）患者具有显著更好的预后，这与 HPV 阴性口咽鳞状细胞癌（OPSCC）在临床、基因组、分子和免疫学方面不同，特别是具有高水平免疫细胞浸润和高度免疫抑制的特征。这篇综述将总结 HPV 阳性 HNSCC 中的免疫逃逸机制，分析宿主对 HPV 的各种免疫反应和大量浸润免疫细胞，并讨论 HPV 阳性 HNSCC 与宫颈癌之间的差异。对免疫景观的更深入了解将有助于免疫检查点肿瘤学中出现新概念，这可能是对现有概念的有价值的补充。
Zotero 插件