基于 Freesurfer 6.0 的磁共振成像阿尔茨海默病脑容量及其比值分析。
Brain volumes and their ratios in Alzheimer´s disease on magnetic resonance imaging segmented using Freesurfer 6.0.
机构信息
National Institute of Mental Health, Topolová 748, Klecany 250 67, Czechia; Charles University, Third Faculty of Medicine, University Hospital Královské Vinohrady, Department of Neurology, AD Center, Šrobárova 50, 100 34 Prague 10, Czechia.
National Institute of Mental Health, Topolová 748, Klecany 250 67, Czechia; Charles University, Third Faculty of Medicine, University Hospital Královské Vinohrady, Department of Neurology, AD Center, Šrobárova 50, 100 34 Prague 10, Czechia.
出版信息
Psychiatry Res Neuroimaging. 2019 May 30;287:70-74. doi: 10.1016/j.pscychresns.2019.01.014. Epub 2019 Mar 19.
Ratios between opposing volumes from brain magnetic resonance imaging (MRI) can provide additional information to volumes in Alzheimer's disease (AD). Brain three-dimensional MPRAGE MRI at 3T were segmented into 44 regions using FreeSurfer v6 in 75 participants. The region's size in absolute volumes and relative proportions to the whole brain volume were compared between 39 AD patients and 36 age-, education- and sex-matched normal controls (NC). Volumes of the most atrophied parts were related to the opposing volumes of the most enlarged parts as ratios. The most atrophic structures in AD were both hippocampi. By contrast, the greatest enlargements in AD were inferior parts of both lateral ventricles. The best ratio for each side was the hippocampo-horn proportion calculated as ratio: the hippocampus / (the hippocampus + inferior lateral ventricle). Its optimal cut-off of 74% yielded sensitivity of 74% and specificity of 78% on the left and sensitivity of 74% and specificity of 78% on the right. The hippocampo-horn proportion is another measure to evaluate the degree of hippocampal atrophy on brain MRI in percentages. It has a potential to be simplified into a comparison of two-dimensional corresponding areas or a visual assessment.
脑磁共振成像（MRI）的对侧体积比可以为阿尔茨海默病（AD）提供额外的信息。在 75 名参与者中，使用 FreeSurfer v6 将三维 MPRAGE MRI 脑分割成 44 个区域。在 39 名 AD 患者和 36 名年龄、教育和性别匹配的正常对照组（NC）之间，比较了各区域的绝对体积和相对于全脑体积的相对比例。最萎缩部分的体积与最增大部分的体积作为比例相关。AD 中最萎缩的结构是两个海马体。相比之下，AD 中最大的增大是两侧侧脑室的下部分。每侧的最佳比例是计算为比例的海马角比例：海马体/（海马体+侧脑室下部分）。其最佳截断值为 74%，在左侧的敏感性为 74%，特异性为 78%，在右侧的敏感性为 74%，特异性为 78%。海马角比例是另一种评估脑 MRI 中海马体萎缩程度的百分比的测量方法。它有可能简化为二维对应区域的比较或直观评估。
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