肺癌筛查队列中肺癌筛查参与者的生存和合并症。
Lung cancer survival and comorbidities in lung cancer screening participants of the Gdańsk screening cohort.
机构信息
Department of Thoracic Surgery, Medical University of Gdańsk, Gdańsk, Poland.
Data Mining Division, Silesian University of Technology, Gliwice, Poland.
出版信息
Eur J Public Health. 2019 Dec 1;29(6):1114-1117. doi: 10.1093/eurpub/ckz052.
BACKGROUND
In 2010, the World Health Organisation recommended implementation of screening programmes in four groups of diseases-neoplasms, cardiovascular diseases (CVD), diabetes mellitus (DM) and chronic obstructive pulmonary disease (COPD). It is due to the fact that they share the same, modifiable risk factors.
METHODS
Between 2009 and 2011, 8637 heavy smokers (aged 50-75, smoking history >20 pack-years) were screened in the Pomeranian Pilot Lung Cancer Screening Programme (PPP) in Gdańsk, Poland. We looked at 5-year follow-up and analysed the medical events and comorbidities of all participants. One health care provider in the Polish health care system provides a unique opportunity to gather most reliable data on all medical events in each person.
RESULTS
In 52.0% of lung cancer screening participants CVD (33.5%), DM (26.0%) and COPD (21.0%) were diagnosed. Prevalence of these diseases is higher in lung cancer patients than in the non-cancer screening group (P < 0.0001). One hundred and seven (1.2%) lung cancers were diagnosed during PPP programme performance and another 382 cases (4.4%) in the 5-year follow-up, so the potential mean annual lung cancer detection rate is 0.77%.
CONCLUSIONS
Lung cancer screening programme offers a great potential for joint screening of lung cancer, CVD, diabetes and COPD.
背景
2010 年，世界卫生组织建议在四类疾病——肿瘤、心血管疾病（CVD）、糖尿病（DM）和慢性阻塞性肺疾病（COPD）——中实施筛查计划。这是因为它们具有相同的、可改变的危险因素。
方法
2009 年至 2011 年，在波兰格但斯克的波美拉尼亚试点肺癌筛查计划（PPP）中对 8637 名重度吸烟者（年龄 50-75 岁，吸烟史>20 包年）进行了筛查。我们观察了 5 年的随访情况，并分析了所有参与者的医疗事件和合并症。波兰医疗体系中的一位医疗保健提供者提供了一个独特的机会，可以收集到每个人所有医疗事件的最可靠数据。
结果
在 52.0%的肺癌筛查参与者中，诊断出了 CVD（33.5%）、DM（26.0%）和 COPD（21.0%）。这些疾病在肺癌患者中的患病率高于非癌症筛查组（P<0.0001）。在 PPP 项目实施期间诊断出 107 例（1.2%）肺癌，在 5 年随访期间又诊断出 382 例（4.4%），因此潜在的平均年度肺癌检出率为 0.77%。
结论
肺癌筛查计划为联合筛查肺癌、CVD、糖尿病和 COPD 提供了巨大的潜力。
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