压力性生活事件与乳腺癌的关系：队列研究的系统评价和荟萃分析。

The relation between stressful life events and breast cancer: a systematic review and meta-analysis of cohort studies.

机构信息

Department of Midwifery, Faculty of Medicine, Social Development and Health Promotion Center, Gonabad University of Medical Sciences, Gonabad, Iran.

Department of Midwifery, Mashhad Branch, Islamic Azad University, Mashhad, Iran.

出版信息

Breast Cancer Res Treat. 2019 Jul;176(1):53-61. doi: 10.1007/s10549-019-05231-x. Epub 2019 Apr 19.

DOI:10.1007/s10549-019-05231-x

PMID:31004298

Abstract

PURPOSE

Breast cancer is the most common cancer among women with high rate of mortality. This systematic review and meta-analysis was conducted to investigate the relation between stressful life events and breast cancer.

METHODS

We searched PubMed, Scopus, ScienceDirect, and Google scholar databases from their inception until June 2018. The keywords and phrases we used in the search were (life events AND stress AND breast cancer OR neoplasm) to identify potentially relevant cohort studies that reported relative risk estimates and confidence intervals of this association. Pooled Risk ratio and 95% confidence intervals (CIs) were calculated using random effects model.

RESULTS

Out of 168 potentially relevant publications, 11 documents met the inclusion criteria. The results showed that history of stressful life events slightly increases the risk of breast cancer [pooled Risk Ratio: 1.11 (95% CI 1.03 to 1.19)].

CONCLUSIONS

History of stressful life events could be associated with a moderate increase in the risk of breast cancer. We advise that receiving psychological and counseling services after occurrence of stressful life events of women should be taken seriously.

摘要

目的

乳腺癌是女性中最常见的癌症，死亡率较高。本系统评价和荟萃分析旨在探讨生活应激事件与乳腺癌之间的关系。

方法

我们检索了 PubMed、Scopus、ScienceDirect 和 Google Scholar 数据库，检索时间从建库至 2018 年 6 月。我们使用的检索词包括（生活事件和应激和乳腺癌或肿瘤），以确定报告该相关性的相对风险估计值和置信区间的潜在相关队列研究。使用随机效应模型计算汇总风险比和 95%置信区间（CI）。