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高血压与乳腺癌风险：系统评价与荟萃分析。

Hypertension and breast cancer risk: a systematic review and meta-analysis.

机构信息

Department of Health Statistics, Second Military Medical University, Shanghai 200433, China.

Department of Cardiology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China.

出版信息

Sci Rep. 2017 Mar 20;7:44877. doi: 10.1038/srep44877.

DOI:10.1038/srep44877
PMID:28317900
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5357949/
Abstract

Observational studies examining the relationship between hypertension and breast cancer risk have reported conflicting findings. We conducted this systematic review and meta-analysis to summarize the evidence regarding the association between hypertension and risk of breast cancer. Eligible studies were identified through a comprehensive literature search of PubMed, EMBASE, and the Cochrane library until August 2016. We included observational studies that reported relative risks (RR) with corresponding 95% confidence intervals (CIs). Results from individual studies were pooled by using a random-effects model. 29 articles of 30 studies, with totally 11643 cases of breast cancer, were eligible for inclusion in the meta-analysis. We observed a statistically significant association between hypertension and increased breast cancer risk (RR: 1.15; 95% CI: 1.08, 1.22). In the subgroup analysis, we found a positive association between hypertension and breast cancer incidence among postmenopausal women (RR: 1.20; 95% CI: 1.09, 1.31). In contrast, hypertension was not associated with risk of breast cancer among premenopausal women (RR: 0.97; 95% CI: 0.84, 1.12) and Asian population (RR: 1.07; 95% CI: 0.94, 1.22).This meta-analysis collectively suggests a significantly association between hypertension and breast cancer risk, specifically for postmenopausal hypertensive women.

摘要

观察性研究检查了高血压与乳腺癌风险之间的关系，报道的结果相互矛盾。我们进行了这项系统综述和荟萃分析，以总结高血压与乳腺癌风险之间关联的证据。通过对 PubMed、EMBASE 和 Cochrane 图书馆进行全面的文献检索，确定了符合条件的研究。我们纳入了报告相对风险（RR）和相应 95%置信区间（CI）的观察性研究。使用随机效应模型汇总来自各个研究的结果。纳入荟萃分析的 29 篇文章来自 30 项研究，共包括 11643 例乳腺癌病例。我们观察到高血压与乳腺癌风险增加之间存在统计学显著关联（RR：1.15；95%CI：1.08，1.22）。在亚组分析中，我们发现高血压与绝经后妇女的乳腺癌发病率之间存在正相关（RR：1.20；95%CI：1.09，1.31）。相比之下，高血压与绝经前妇女（RR：0.97；95%CI：0.84，1.12）和亚洲人群（RR：1.07；95%CI：0.94，1.22）的乳腺癌风险无关。这项荟萃分析总体表明高血压与乳腺癌风险之间存在显著关联，特别是对于绝经后高血压妇女。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73fa/5357949/58ebc6992bef/srep44877-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73fa/5357949/6fb3434f16b3/srep44877-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73fa/5357949/d7b2e12ffdb3/srep44877-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73fa/5357949/02dcfacd171c/srep44877-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73fa/5357949/58ebc6992bef/srep44877-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73fa/5357949/6fb3434f16b3/srep44877-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73fa/5357949/d7b2e12ffdb3/srep44877-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73fa/5357949/02dcfacd171c/srep44877-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73fa/5357949/58ebc6992bef/srep44877-f4.jpg

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