State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.
Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, 100101, China.
Protein Cell. 2020 Jan;11(1):23-33. doi: 10.1007/s13238-019-0625-0. Epub 2019 Apr 19.
Diploidy is the typical genomic mode in all mammals. Haploid stem cells are artificial cell lines experimentally derived in vitro in the form of different types of stem cells, which combine the characteristics of haploidy with a broad developmental potential and open the possibility to uncover biological mysteries at a genomic scale. To date, a multitude of haploid stem cell types from mouse, rat, monkey and humans have been derived, as more are in development. They have been applied in high-throughput genetic screens and mammalian assisted reproduction. Here, we review the generation, unique properties and broad applications of these remarkable cells.
二倍体是所有哺乳动物的典型基因组模式。 单倍体干细胞是通过不同类型的干细胞体外实验获得的人工细胞系，它们结合了单倍体的特性和广泛的发育潜力，并为在基因组范围内揭示生物学奥秘开辟了可能性。 迄今为止，已经从老鼠、大鼠、猴子和人类中衍生出了多种单倍体干细胞类型，并且还有更多的类型正在开发中。 它们已被应用于高通量遗传筛选和哺乳动物辅助生殖。 在这里，我们回顾了这些非凡细胞的产生、独特特性和广泛应用。
