Department of Life Science and Technology, Tokyo Institute of Technology, Tokyo, Japan.
Bioinformatics. 2019 Nov 1;35(21):4519-4521. doi: 10.1093/bioinformatics/btz245.
Functional annotations and their hierarchical classification are widely used in omics workflows to build novel insight upon existing biological knowledge. Currently, a plethora of tools is available to explore omics datasets at the level of functional annotations, but there is a lack of feature rich and user-friendly tools that help scientists take advantage of their hierarchical classification for additional and often invaluable insights. Here, we present FuncTree2, a user-friendly web application that turns hierarchical classifications into interactive and highly customizable radial trees, and enables researchers to visualize their data simultaneously on all its levels. FuncTree2 features mapping of data from multiple samples and several navigation features like zooming, panning, re-rooting and collapsing of nodes or levels.
FuncTree2 is freely available at https://bioviz.tokyo/functree2/ as a web application and a REST API. Source code is available on GitHub https://github.com/yamada-lab/functree-ng.
Supplementary data are available at Bioinformatics online.
功能注释及其层次分类在组学工作流程中被广泛应用，以在现有生物学知识的基础上建立新的见解。目前，有大量的工具可用于在功能注释层面上探索组学数据集，但缺乏功能丰富且用户友好的工具，帮助科学家利用其层次分类获得更多、通常非常有价值的见解。在这里，我们介绍了 FuncTree2，这是一个用户友好的 Web 应用程序，它将层次分类转化为交互式和高度可定制的径向树，并使研究人员能够在所有层次上同时可视化他们的数据。FuncTree2 具有将来自多个样本的数据映射的功能，以及缩放、平移、重新根节点或级别以及节点折叠等导航功能。
FuncTree2 可在 https://bioviz.tokyo/functree2/ 作为一个 Web 应用程序和一个 REST API 免费使用。源代码可在 GitHub https://github.com/yamada-lab/functree-ng 上获得。
补充数据可在 Bioinformatics 在线获得。
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