Gola Agnieszka, Pietrańczyk Rafał, Musiał Witold
Department of Physical Chemistry and Biophysics, Pharmaceutical Faculty, Wroclaw Medical University, Borowska 211, 50-556 Wroclaw, Poland.
Polymers (Basel). 2024 Jul 5;16(13):1917. doi: 10.3390/polym16131917.
Six derivatives of poly--vinylcaprolactam (PNVCL) P1-P6 were synthesized via surfactant-free precipitation polymerization (SFPP) at 70 °C, with potassium persulfate (KPS) as the initiator. P5 and P6 were synthesized using the cross-linker ,'-Methylenebisacrylamide (MBA). The conductivity was measured to monitor the polymerization process. The hydrodynamic diameters (HDs) and polydispersity indexes (PDIs) of aqueous dispersions of P1-P6 were determined using dynamic light scattering (DLS) and zeta potential (ZP) using electrophoretic mobilities. At 18 °C for P1-P6, the HDs (nm) were 428.32 ± 81.30 and PDI 0.31 ± 0.19, 528.60 ± 84.70 (PDI 0.42 ± 0,04), 425.96 ± 115.42 (PDI 0.56 ± 0.08), 440.34 ± 106.40 (PDI 0.52 ± 0.09), 198.39 ± 225.35 (PDI 0.40 ± 0.19), and 1201.52 ± 1318.05 (PDI 0.71 ± 0.30), the and ZPs were (mV) 0.90 ± 3.23, -4.46 ± 1.22, -6.44 ± 1.82, 0.22 ± 0.48, 0.18 ± 0.79, and -0.02 ± 0.39 for P1-P6, respectively. The lower critical solution temperature ranged from 27 to 29 °C. The polymers were characterized using the ATR-FTIR method. The study concluded that the physicochemical properties of the product were significantly affected by the initial reaction parameters. Polymers P1-P4 and P6 have potential for use as drug carriers for skin applications.
通过在70°C下以过硫酸钾（KPS）为引发剂的无表面活性剂沉淀聚合（SFPP）合成了六种聚 - 乙烯基己内酰胺（PNVCL）衍生物P1 - P6。使用交联剂N,N'-亚甲基双丙烯酰胺（MBA）合成了P5和P6。测量电导率以监测聚合过程。使用动态光散射（DLS）测定P1 - P6水分散体的流体动力学直径（HDs）和多分散指数（PDIs），并使用电泳迁移率测定zeta电位（ZP）。对于P1 - P6，在18°C时，HDs（nm）分别为428.32±81.30和PDI 0.31±0.19、528.60±84.70（PDI 0.42±0.04）、425.96±115.42（PDI 0.56±0.08）、440.34±106.40（PDI 0.52±0.09）、198.39±225.35（PDI 0.40±0.19）和1201.52±1318.05（PDI 0.71±0.30），ZP（mV）分别为0.90±3.23、 - 4.46±1.22、 - 6.44±1.82、0.22±0.48、0.18±0.79和 - 0.02±0.39。最低临界溶液温度范围为27至29°C。使用衰减全反射傅里叶变换红外光谱（ATR - FTIR）方法对聚合物进行了表征。该研究得出结论，产物的物理化学性质受到初始反应参数的显著影响。聚合物P1 - P4和P6有潜力用作皮肤应用的药物载体。
