Li Zhaoyuan, Peng Shouxin, Chen Meijin, Sun Jinhui, Liu Feifei, Wang Huaiji, Xiang Hao
Department of Global Health, School of Public Health, Wuhan University, 115# Donghu Road, Wuhan, 430071, China; Global Health Institute, Wuhan University, 115# Donghu Road, Wuhan, 430071, China.
Wuhan Center for Disease Control and Prevention, 288# Machang Road, Wuhan, 430024, China.
Environ Res. 2023 Jan 15;217:114739. doi: 10.1016/j.envres.2022.114739. Epub 2022 Nov 8.
Evidence is needed to elucidate the association of blood pressure (BP) changes with metal constituents in fine particulate matter (PM). Therefore, we designed a longitudinal panel study enrolling 70 healthy students from Wuhan University in the context of the seventh World Military Games (the 7th WMG) from September 2019 to January 2020. A total of eight visits were conducted before, during, and after the 7th WMG. During every visit, each participant was asked to carry a personal PM monitor to measure hourly PM levels for three consecutive days. Questionnaire investigation and physical examination were completed on the fourth day. We analyzed ten metal constituents of ambient PM collected from the fixed station, and blood pressure was recorded during each visit. The linear mixed-effects models were performed to evaluate associations of metal constituents and blood pressure measurements. We observed a dramatic variation of PM concentration ranging from 7.38 to 132.04 μg/m. A 10 μg/m increment of PM was associated with an increase of 0.64 mmHg (95% CI: 0.44, 0.84) in systolic BP (SBP), 0.40 mmHg (0.26, 0.54) in diastolic BP (DBP), 0.31 mmHg (0.15, 0.47) in pulse pressure (PP) and 0.44 mmHg (0.26, 0.62) in mean artery pressure (MAP), respectively. For metal constituents in PM, robust positive associations were observed between BP and selenium, manganese, arsenic, cadmium, and thallium. For example, for an IQR (0.93 ng/m) increment of selenium, SBP and MAP elevated by 0.98 mmHg (0.09, 1.87) and 0.71 mmHg (0.03, 1.39), respectively. Aluminum was found to be robustly associated with decreased SBP, DBP, and MAP. The study indicated that exposure to PM total mass and metal constituents including selenium, manganese, arsenic, cadmium, and thallium were associated with the elevated BP.
需要证据来阐明血压（BP）变化与细颗粒物（PM）中金属成分之间的关联。因此，我们设计了一项纵向队列研究，在2019年9月至2020年1月第七届世界军人运动会（第七届军运会）期间，招募了70名来自武汉大学的健康学生。在第七届军运会之前、期间和之后共进行了八次访视。每次访视期间，要求每位参与者佩戴个人PM监测仪，连续三天每小时测量PM水平。在第四天完成问卷调查和体格检查。我们分析了从固定站点收集的环境PM的十种金属成分，并在每次访视时记录血压。采用线性混合效应模型来评估金属成分与血压测量值之间的关联。我们观察到PM浓度变化很大，范围为7.38至132.04μg/m。PM每增加10μg/m，收缩压（SBP）升高0.64mmHg（95%CI：0.44，0.84），舒张压（DBP）升高0.40mmHg（0.26，0.54），脉压（PP）升高0.31mmHg（0.15，0.47），平均动脉压（MAP）升高0.44mmHg（0.26，0.62）。对于PM中的金属成分，在血压与硒、锰、砷、镉和铊之间观察到显著的正相关。例如，硒每增加一个四分位数间距（IQR，0.93ng/m），SBP和MAP分别升高0.98mmHg（0.09，1.87）和0.71mmHg（0.03，1.39）。发现铝与SBP、DBP和MAP降低密切相关。该研究表明，暴露于PM总量以及包括硒、锰、砷、镉和铊在内的金属成分与血压升高有关。
