Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing, 100069, PR China; Department of Occupational and Environmental Health, School of Public Health, Capital Medical University, Beijing, 100069, PR China.
Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing, 210009, PR China.
Environ Pollut. 2022 Mar 1;296:118746. doi: 10.1016/j.envpol.2021.118746. Epub 2021 Dec 27.
Considerable investigations have been carried out to address the relationship between ambient fine particulate matter (PM) and blood pressure (BP) in patients with hypertension. However, few studies have explored the influence of PM and its constituents on Trimethylamine N-oxide (TMAO), an established risk factor for hypertension and cardiovascular disease (CVD), particularly in severely air-polluted areas. To explore the potential impact of PM constituents on BP, plasma hormones, and TMAO, a panel study was conducted to investigate changes in BP, plasma hormones, and TMAO in response to ambient air pollution exposure in stage 1 hypertensive young adults. Linear mixed effect models were used to estimate the cumulative effects of fine particulate matters (PM) and its constituents on BP, plasma hormones and TMAO. We found that one interquartile range (IQR) (35 μg/m) increase in 0-1 day moving-average PM concentrations was statistically significantly associated with elevated systolic blood pressure (SBP), diastolic blood pressure (DBP), and mean arterial pressure (MAP) with estimated values of 0.13 (95% confidence interval (CI): 0.03 to 0.23) mmHg, 0.18 (95% CI: 0.08 to 0.28) mmHg, and 0.17 (95% CI: 0.09 to 0.26) mmHg, respectively. Hormone disturbance in the renin-angiotensin-aldosterone system was also associated with PM exposure. Elevated TMAO levels with an IQR increase for 0-4, 0-5, 0-6 moving-average concentrations of PM were found, and the increased values ranged from 26.28 (95% CI: 2.92 to 49.64) to 60.78 (31.95-89.61) ng/ml. More importantly, the PM-bound metal constituents, such as manganese (Mn), titanium (Ti), and selenium (Se) showed robust associations with elevated BP and plasma TMAO levels. This study demonstrates associations between PM metal constituents and increased BP, changes in plasma hormones and TMAO, in stage 1 hypertensive young adults. Source control, aiming to reduce the emission of PM-bound metals should be implemented to reduce the risk of hypertension and CVD.
已经进行了大量研究来探讨环境细颗粒物 (PM) 与高血压患者血压之间的关系。然而，很少有研究探讨 PM 及其成分对氧化三甲胺 (TMAO) 的影响，TMAO 是高血压和心血管疾病 (CVD) 的一个既定危险因素，特别是在空气污染严重的地区。为了探讨 PM 成分对血压、血浆激素和 TMAO 的潜在影响，进行了一项面板研究，以调查在 1 期高血压青年中，大气污染暴露对血压、血浆激素和 TMAO 的影响。线性混合效应模型用于估计细颗粒物 (PM) 及其成分对血压、血浆激素和 TMAO 的累积影响。我们发现，0-1 天移动平均 PM 浓度的一个四分位距 (IQR) (35μg/m) 增加与收缩压 (SBP)、舒张压 (DBP) 和平均动脉压 (MAP) 的升高呈统计学显著相关，估计值分别为 0.13 (95%置信区间 (CI): 0.03 至 0.23) mmHg、0.18 (95% CI: 0.08 至 0.28) mmHg 和 0.17 (95% CI: 0.09 至 0.26) mmHg。肾素-血管紧张素-醛固酮系统的激素紊乱也与 PM 暴露有关。发现随着 PM0-4、0-5 和 0-6 移动平均浓度的增加，TMAO 水平升高，增加的值范围为 26.28 (95%CI: 2.92 至 49.64) 至 60.78 (31.95-89.61) ng/ml。更重要的是，PM 结合的金属成分，如锰 (Mn)、钛 (Ti) 和硒 (Se)，与血压升高和血浆 TMAO 水平升高呈显著关联。这项研究表明，在 1 期高血压青年中，PM 金属成分与血压升高、血浆激素和 TMAO 变化之间存在关联。应该实施源头控制，旨在减少 PM 结合金属的排放，以降低高血压和 CVD 的风险。
