急性肠套叠婴儿血清P物质和血管活性肠肽水平
Serum substance P and vasoactive intestinal peptide levels in infants with acute intussusception.
作者信息
Zhu Zhen-Chuang, Wang Hai-Bin, Yan Xue-Qiang, Yang Jun, Duan Xu-Fei, Bian Hong-Qiang, Kuang Hou-Fang
机构信息
Wuhan Children's Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, China.
出版信息
J Int Med Res. 2019 Jun;47(6):2446-2451. doi: 10.1177/0300060519844401. Epub 2019 Apr 21.
OBJECTIVE
We aimed to investigate the role of the intestinal neurotransmitters vasoactive intestinal peptide (VIP) and substance P (SP) at different time points in infants with acute intussusception.
METHODS
Thirty patients who were diagnosed with acute intussusception were enrolled in the study and classified as the experimental group. Another 30 patients with an indirect inguinal hernia who had no intestinal injury were included as the control group. Serum SP and VIP levels at different time points, including pre- and postoperation, were detected by enzyme-linked immunosorbent assay and compared between the two groups.
RESULTS
Serum SP levels in patients with acute intussusception were significantly higher than those in controls. However, with recovery of acute intussusception, SP levels gradually decreased after treatment. Serum VIP levels in patients with acute intussusception were significantly lower than those in controls. However, with recovery of acute intussusception, VIP levels gradually increased after treatment.
CONCLUSIONS
SP and VIP levels may have a potential relationship with the pathogenetic process of intussusception.
目的
我们旨在研究肠道神经递质血管活性肠肽（VIP）和P物质（SP）在急性肠套叠婴儿不同时间点的作用。
方法
30例被诊断为急性肠套叠的患者纳入本研究并分类为实验组。另外30例无肠道损伤的腹股沟斜疝患者作为对照组。通过酶联免疫吸附测定法检测不同时间点（包括术前和术后）的血清SP和VIP水平，并在两组之间进行比较。
结果
急性肠套叠患者的血清SP水平显著高于对照组。然而，随着急性肠套叠的恢复，治疗后SP水平逐渐下降。急性肠套叠患者的血清VIP水平显著低于对照组。然而，随着急性肠套叠的恢复，治疗后VIP水平逐渐升高。
结论
SP和VIP水平可能与肠套叠的发病过程存在潜在关系。
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