Shan Pei Wei, Liu Wei, Liu Caixing, Han Yunyi, Wang Lina, Chen Qinggang, Tian Hongjun, Sun Xiuhai, Luan Shuxin, Lin Xiaodong, Jiang Deguo, Zhuo Chuanjun
1 Department of Psychiatry, Wenzhou Seventh People's Hospital, Wenzhou, Zhejiang Province, China.
2 Department of Psychiatry, The First Affiliated Hospital of Harbin Medical University, Harbin City, Heilongjiang Province, China.
J Int Med Res. 2019 Jun;47(6):2434-2445. doi: 10.1177/0300060518807058. Epub 2019 Apr 21.
Functional connectivity (FC) is altered in patients with obsessive-compulsive disorder (OCD). Most previous studies have focused on the strength of FC in patients with OCD; few have examined the number of functional connections in these patients. The number of functional connections is an important index for assessing aberrant FC. In the present study, we used FC density (FCD) mapping to explore alterations in the number of functional connections in patients with treatment-refractory OCD (TROCD) using the FCD index.
Twenty patients with TROCD and 20 patients with OCD in clinical remission were enrolled in the study. Global FCD (gFCD) was adopted to compare the differences between the two groups of patients.
The gFCD in the left middle temporal gyrus was lower in the patients with TROCD than in those with remitted OCD, suggesting that decreased information processing ability may play a significant role in TROCD.
The left middle temporal gyrus is a key component of the emotional processing circuit and attentional processing circuit. Decreased information processing ability in this brain region may play a significant role in TROCD; however, further well-designed follow-up studies are needed to support this hypothesis.
强迫症（OCD）患者的功能连接（FC）会发生改变。以往大多数研究都集中在OCD患者的FC强度上；很少有研究考察这些患者的功能连接数量。功能连接数量是评估异常FC的一个重要指标。在本研究中，我们使用FC密度（FCD）映射，通过FCD指数来探究难治性OCD（TROCD）患者功能连接数量的变化。
本研究纳入了20例TROCD患者和20例临床缓解的OCD患者。采用全局FCD（gFCD）来比较两组患者之间的差异。
TROCD患者左侧颞中回的gFCD低于缓解期OCD患者，这表明信息处理能力下降可能在TROCD中起重要作用。
左侧颞中回是情绪处理回路和注意力处理回路的关键组成部分。该脑区信息处理能力下降可能在TROCD中起重要作用；然而，需要进一步设计良好的随访研究来支持这一假设。
