University of Arkansas for Medical Sciences , Little Rock , Arkansas , USA.
National Liver Institute, Menoufiya University , Menoufiya , Egypt.
Nutr Cancer. 2019;71(7):1118-1131. doi: 10.1080/01635581.2019.1597901. Epub 2019 Apr 22.
This is a case-cohort study to examine whether the excess of liver cancer deaths observed in workers in poultry plants could be explained by oncogenic viruses and chemical carcinogenic exposures within the plants. A detailed telephone questionnaire was administered, and responses were analyzed by logistic regression. Odds ratios for several indicators of high exposure to oncogenic viruses or chemical carcinogens in poultry plants and related industries were elevated, but not statistically significant, except the odds ratio for direct contact with the blood of meat in kitchens, eating places, etc. Established risk factors were replicated, and new ones identified. The study was unable to unequivocally assess risks due to oncogenic viruses or chemical carcinogenic exposures in poultry plants, mainly because observed elevated risks did not achieve statistical significance. The same also applies to some non-occupational factors. Noteworthy risk factors identified include the risks for eating cabbage, mussels, blood sausage, meringue, playing football, and risks for history of frequent intake of soft drinks, gelatin-based meals, vitamins, frequent use of microwave oven to cook, and history of childhood diseases, and nonspecific symptoms. The significance of these findings is unknown, and they will need to be replicated in studies with adequate statistical power.
这是一项病例-队列研究，旨在探讨在禽类加工厂工作的工人肝癌死亡率过高是否可以归因于工厂内致癌病毒和化学致癌物质的暴露。通过电话进行了详细的问卷调查，并通过逻辑回归分析了应答结果。除了与厨房、饮食场所等肉类直接接触的血液有关的比值比外，禽类加工厂和相关行业中几种致癌病毒或化学致癌物质高暴露的指标比值升高，但无统计学意义。已确定的风险因素得到了复制，并且还确定了新的风险因素。由于禽类加工厂中致癌病毒或化学致癌物质暴露的风险无法明确评估，该研究主要是因为观察到的风险升高没有达到统计学意义。这同样适用于一些非职业因素。确定的值得注意的风险因素包括食用卷心菜、贻贝、血肠、蛋白酥皮、踢足球的风险，以及经常饮用软饮料、明胶类膳食、维生素、经常使用微波炉烹饪以及儿时患病和非特异性症状的风险。这些发现的意义尚不清楚，需要在具有足够统计能力的研究中进行复制。
