Netto G F, Johnson E S
Tulane University School of Public Health and Tropical Medicine, New Orleans, LA 70112, USA.
Occup Environ Med. 2003 Oct;60(10):784-8. doi: 10.1136/oem.60.10.784.
Subjects who work in poultry slaughtering and processing plants have one of the highest human exposures to viruses that cause cancer in chickens and turkeys. It is not known whether these viruses cause cancer in humans also. Epidemiological studies investigating this issue are scarce.
Mortality was studied during the period 1969-90 in a cohort of 7700 subjects who worked in poultry slaughtering and processing plants and were members of a local poultry union in the State of Missouri.
Statistically significant excess risks of non-malignant respiratory diseases, accidents, and symptoms, senility, and ill-defined conditions, and increased but not statistically significant excesses for some cancers were observed in particular race/sex groups. Most of these results were based on small numbers of deaths, and in many cases were evident only in particular subgroups of the cohort. Because of this and the multiple comparisons made, chance could not be ruled out in explaining the findings. Furthermore, the cohort is young, with only 6% deceased at the end of follow up. Further follow up of this cohort is required before a reliable assessment of the potential risk associated with these viruses can be made.
在禽类屠宰和加工厂工作的人员，是人类接触导致鸡和火鸡患癌病毒比例最高的群体之一。目前尚不清楚这些病毒是否也会导致人类患癌。针对此问题的流行病学研究较少。
对1969年至1990年期间，密苏里州一个当地禽类工会的7700名在禽类屠宰和加工厂工作的人员组成的队列进行了死亡率研究。
在特定种族/性别群体中，观察到非恶性呼吸道疾病、事故、症状、衰老和不明病症存在统计学上显著的超额风险，某些癌症的超额风险虽有所增加但无统计学意义。这些结果大多基于少量死亡病例，且在许多情况下仅在队列的特定亚组中明显。鉴于此以及进行的多次比较，在解释这些发现时无法排除偶然性。此外，该队列较为年轻，随访结束时仅有6%的人死亡。在对与这些病毒相关的潜在风险进行可靠评估之前，需要对该队列进行进一步随访。
