Gandhi S, Felini M J, Ndetan H, Cardarelli K, Jadhav S, Faramawi M, Johnson E S
a Department of Epidemiology , University of North Texas Health Science Center , Fort Worth , Texas , USA.
Nutr Cancer. 2014;66(3):343-50. doi: 10.1080/01635581.2013.878734. Epub 2014 Feb 24.
We conducted an exploratory study to investigate which exposures (including poultry oncogenic viruses) are associated with brain cancer in poultry workers. A total of 46,819 workers in poultry and nonpoultry plants from the same union were initially followed for mortality. Brain cancer was observed to be in excess among poultry workers. Here we report on a pilot case-cohort study with cases consisting of 26 (55%) of the 47 brain cancer deaths recorded in the cohort, and controls consisting of a random sample of the cohort (n = 124). Exposure information was obtained from telephone interviews, and brain cancer mortality risk estimated by odds ratios. Increased risk of brain cancer was associated with killing chickens, odds ratio (OR) = 5.8 (95% confidence interval, 1.2-28.3); working in a shell-fish farm, OR = 13.0 (95% CI, 1.9-84.2); and eating uncooked fish, OR = 8.2 (95% CI, 1.8-37.0). Decreased risks were observed for chicken pox illness, OR = 0.2 (95% CI, 0.1-0.6), and measles vaccination, OR = 0.2 (95% CI, 0.1-0.6). Killing chickens, an activity associated with the highest occupational exposure to poultry oncogenic viruses, was associated with brain cancer mortality, as were occupational and dietary shellfish exposures. These findings are novel.
我们开展了一项探索性研究，以调查哪些暴露因素（包括家禽致癌病毒）与家禽业工人患脑癌有关。最初对来自同一工会的家禽厂和非家禽厂的46,819名工人进行了死亡率随访。结果发现家禽业工人的脑癌发病率过高。在此，我们报告一项病例队列试点研究，病例组包括队列中记录的47例脑癌死亡病例中的26例（55%），对照组为该队列的随机样本（n = 124）。通过电话访谈获取暴露信息，并通过比值比估计脑癌死亡风险。脑癌风险增加与杀鸡有关，比值比（OR）= 5.8（95%置信区间，1.2 - 28.3）；在贝类养殖场工作，OR = 13.0（95%置信区间，1.9 - 84.2）；以及食用生鱼，OR = 8.2（95%置信区间，1.8 - 37.0）。水痘患病风险降低，OR = 0.2（95%置信区间，0.1 - 0.6），麻疹疫苗接种风险降低，OR = 0.2（95%置信区间，0.1 - 0.6）。杀鸡这一与职业接触家禽致癌病毒程度最高相关的活动，与脑癌死亡率有关，职业和饮食中贝类接触也与之有关。这些发现很新颖。
