Peters E, Gardner D G, Altini M, Crooks J
J Oral Pathol. 1986 Sep;15(8):454-8. doi: 10.1111/j.1600-0714.1986.tb00657.x.
The histopathologic features characteristic of the inflammatory response associated with starch powder used as a lubricant for surgical gloves were investigated by implanting starch granules into 3 separate sites on the right side of 8 male Wistar rats. On the opposite side, a sham-operated site and sites implanted with talc were used as controls. Two rats were killed at 1, 2, 3 & 4-week intervals and tissue from the implanted sites was assessed for distinctive features. It was found that a consistent feature of the starch-implanted sites was the presence of large histiocytes containing prominent PAS-positive, diastase-resistant inclusions. These cells were not found in the control sites and, thus, were considered characteristic of starch contamination in tissue, even in the absence of identifiable starch granules. A possible clinical case of reaction to starch, identified retrospectively, using these results is discussed.
通过将淀粉颗粒植入8只雄性Wistar大鼠右侧的3个不同部位，研究了用作手术手套润滑剂的淀粉粉末所引发的炎症反应的组织病理学特征。在另一侧，将假手术部位和植入滑石粉的部位用作对照。每隔1、2、3和4周处死2只大鼠，并评估植入部位的组织是否有明显特征。结果发现，淀粉植入部位的一个一致特征是存在含有显著PAS阳性、抗淀粉酶包涵体的大型组织细胞。在对照部位未发现这些细胞，因此，即使在没有可识别淀粉颗粒的情况下，这些细胞也被认为是组织中淀粉污染的特征。本文讨论了利用这些结果回顾性确定的一例可能的淀粉反应临床病例。
