Nordstrand K, Melhus O, Eide T J, Larsen T, Giercksky K E
Acta Pathol Microbiol Immunol Scand A. 1987 Mar;95(2):93-8. doi: 10.1111/j.1699-0463.1987.tb00012_95a.x.
A total of 32 Wistar rats were given 1, 10, 100 and 1000 mg glove powder (Biosorb) intraperitoneally for 4, 11, 18 or 25 days. Four control rats received physiological saline. Examination of the abdominal cavity displayed granulomatous inflammation which was clearly dose-dependent in the experimental animal, but not in the controls. A biphasic time-sequence of the granulomatous reaction was observed in those rats receiving 100 and 1000 mg Biosorb with a minimum at day 18. The mean size of the granules (8.1 microns) within the inflammatory tissue was almost identical with the size of powder granules found on the external surface of the gloves (8.8 microns). X-ray microanalysis demonstrated maize-starch additives of magnesium and aluminium. The study indicates a foreign body reaction to maize-starch. In addition, immunological factors may play a role later in the development of the disease.
总共32只Wistar大鼠分别腹腔注射1、10、100和1000毫克手套粉末（Biosorb），持续4、11、18或25天。四只对照大鼠注射生理盐水。腹腔检查显示，实验动物出现肉芽肿性炎症，且明显呈剂量依赖性，而对照组未出现。在接受100和1000毫克Biosorb的大鼠中观察到肉芽肿反应的双相时间序列，在第18天达到最小值。炎症组织内颗粒的平均大小（8.1微米）与手套外表面发现的粉末颗粒大小（8.8微米）几乎相同。X射线微量分析表明存在镁和铝的玉米淀粉添加剂。该研究表明对玉米淀粉有异物反应。此外，免疫因素可能在疾病后期发展中起作用。
