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中东地区的哮喘与肥胖:概述

Asthma and obesity in the Middle East region: An overview.

作者信息

Hammoudeh Samer, Gadelhak Wessam, Janahi Ibrahim A

机构信息

Medical Research Center, Research Affairs, Hamad Medical Corporation, Doha, Qatar.

Pediatric Pulmonology, Hamad Medical Corporation, Doha, Qatar.

出版信息

Ann Thorac Med. 2019 Apr-Jun;14(2):116-121. doi: 10.4103/atm.ATM_115_18.

DOI:10.4103/atm.ATM_115_18
PMID:31007762
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6467016/
Abstract

This paper aims to cover the current status of asthma and obesity in the Middle East, as well as to introduce the various studies tying the two diseases; further expanding on the proposed mechanisms. Finally, the paper covers recent literature related to sphingolipids and its role in asthma, followed by recommendations and future directions. In preparation of this paper, we searched PubMed and Google Scholar, with no restrictions, using the following terms; asthma, obesity, Middle East, sphingolipids. We also used the reference list of retrieved articles to further expand on the pool of articles that were used for this review.

摘要

本文旨在阐述中东地区哮喘与肥胖的现状,介绍将这两种疾病联系起来的各类研究;进一步详述所提出的相关机制。最后,本文涵盖了与鞘脂及其在哮喘中的作用相关的近期文献,随后给出了建议和未来研究方向。在撰写本文时,我们在无限制条件下搜索了PubMed和谷歌学术,使用了以下检索词:哮喘、肥胖、中东、鞘脂。我们还利用检索到的文章的参考文献列表,进一步扩充了用于本综述的文章库。

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本文引用的文献

1
Pathophysiology to Phenotype in the Asthma of Obesity.肥胖型哮喘的病理生理学表现与表型。
Ann Am Thorac Soc. 2017 Nov;14(Supplement_5):S395-S398. doi: 10.1513/AnnalsATS.201702-122AW.
2
Prevalence of asthma among Middle Eastern children: A systematic review.中东儿童哮喘患病率:一项系统评价。
Med J Islam Repub Iran. 2016 Oct 2;31:9. doi: 10.18869/mjiri.31.9. eCollection 2017.
3
Trend of Overweight and Obesity, Based on Population Study among School Children in North West of Iran: Implications for When to Intervene.基于伊朗西北部学童群体研究的超重和肥胖趋势:干预时机的影响因素
Maedica (Bucur). 2015 Sep;10(3):214-220.
4
Sphingolipids, ORMDL3 and asthma: what is the evidence?鞘脂、ORMDL3与哮喘:有哪些证据?
Curr Opin Clin Nutr Metab Care. 2017 Mar;20(2):99-103. doi: 10.1097/MCO.0000000000000349.
5
Asthma and obesity: mechanisms and clinical implications.哮喘与肥胖:机制及临床意义
Asthma Res Pract. 2015 Jun 4;1:1. doi: 10.1186/s40733-015-0001-7. eCollection 2015.
6
17q21 asthma-risk variants switch CTCF binding and regulate IL-2 production by T cells.17q21 哮喘风险变异改变 CTCF 结合并调节 T 细胞产生 IL-2。
Nat Commun. 2016 Nov 16;7:13426. doi: 10.1038/ncomms13426.
7
Mechanisms by which obesity impacts upon asthma.肥胖影响哮喘的机制。
Thorax. 2017 Feb;72(2):174-177. doi: 10.1136/thoraxjnl-2016-209130. Epub 2016 Sep 26.
8
Trends in Obesity Prevalence Among Children and Adolescents in the United States, 1988-1994 Through 2013-2014.1988 - 1994年至2013 - 2014年美国儿童和青少年肥胖患病率趋势
JAMA. 2016 Jun 7;315(21):2292-9. doi: 10.1001/jama.2016.6361.
9
Pediatric Obesity-Related Asthma: The Role of Metabolic Dysregulation.儿童肥胖相关哮喘:代谢失调的作用
Pediatrics. 2016 May;137(5). doi: 10.1542/peds.2015-0812. Epub 2016 Apr 8.
10
The role of ORMDL proteins, guardians of cellular sphingolipids, in asthma.ORMDL 蛋白在细胞神经鞘脂中的作用与哮喘
Allergy. 2016 Jul;71(7):918-30. doi: 10.1111/all.12877. Epub 2016 Mar 29.