Mirzaei Masoud, Karimi Mehran, Beheshti Shima, Mohammadi Masoud
Yazd Cardiovascular Research Centre, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Department of Pediatrics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Med J Islam Repub Iran. 2016 Oct 2;31:9. doi: 10.18869/mjiri.31.9. eCollection 2017.
The prevalence of asthma and allergy has increased during the last decades, especially in children. However, little is known about it in the Middle East region. This systematic review is aimed to estimate the prevalence of asthma among the Middle Eastern children. Local and international scientific databases including SID, Iranmedex, Medline and Science Direct were systematically searched for relevant keywords including; asthma, prevalence, children, International Study of Asthma and Allergies in Childhood (ISACC) and the names of Middle Eastern countries for the period of 1996-2011. Papers in Persian and English which met the defined criteria were included into the study. Bibliographies of the extracted articles were also searched. After extraction of data, heterogeneity between studies and publication bias were measured using Egger's-test. Effect size was pooled by the random-effect model. Since significant heterogeneity was found between studies, univariate meta-regression analyses were done to assess the association of variables with the overall results. Fifty studies in the Middle East examined the prevalence of asthma and allergy in children under the age of 18 years according to the ISAAC criteria and were included. A total number of 289,717 children were examined in the included studies and the prevalence varied from 0.7 % in Isfahan to 22.3 % in Bagdad. The total prevalence of diagnosed asthma was calculated 7.53 % (95% Cl: 6.38-8.75). Prevalence of asthma in the 13-14 years age group was 7.57% (95% Cl: 5.78-9.29) and in 6-7 years age group was 7.43% (95% Cl: 5.75-9.10). The prevalence of asthma among girls, based on random effect model, was 6.30% (95% Cl: 4.97-7.61) and among boys, it was 8.91% (95% Cl: 6.80-11.04). The prevalence of asthma in the Middle East is lower than most developed countries. However, there is not enough longitudinal data to estimate the trend over time. In order to have more accurate estimates and to provide evidence for proper planning, standard epidemiologic studies should be conducted in countries of the region.
在过去几十年间，哮喘和过敏症的患病率呈上升趋势，尤其是在儿童中。然而，中东地区对此的了解却很少。本系统评价旨在估计中东地区儿童哮喘的患病率。我们系统检索了包括SID、伊朗医学数据库、医学索引数据库和科学Direct在内的国内外科学数据库，搜索了相关关键词，包括：哮喘、患病率、儿童、儿童哮喘和过敏国际研究（ISACC）以及中东国家名称，检索时间跨度为1996年至2011年。符合既定标准的波斯语和英语论文被纳入研究。还对提取文章的参考文献进行了检索。数据提取后，使用Egger检验测量研究间的异质性和发表偏倚。效应量通过随机效应模型进行合并。由于研究间存在显著异质性，因此进行了单变量meta回归分析，以评估变量与总体结果之间的关联。中东地区有50项研究根据ISAAC标准对18岁以下儿童哮喘和过敏的患病率进行了调查，并被纳入研究。纳入研究共检查了289,717名儿童，患病率从伊斯法罕的0.7%到巴格达的22.3%不等。诊断哮喘的总患病率经计算为7.53%（95%可信区间：6.38 - 8.75）。13 - 14岁年龄组哮喘患病率为7.57%（95%可信区间：5.78 - 9.29），6 - 7岁年龄组为7.43%（95%可信区间：5.75 - 9.10）。基于随机效应模型，女孩哮喘患病率为6.30%（95%可信区间：4.97 - 7.61），男孩为8.91%（95%可信区间：6.80 - 11.04）。中东地区哮喘的患病率低于大多数发达国家。然而，目前尚无足够的纵向数据来估计随时间的变化趋势。为了获得更准确的估计并为合理规划提供证据，该地区各国应开展标准的流行病学研究。
